recombination — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T82455	Epoetin beta	Genetical recombination,rhEPO,EPOCH
	Epoetin beta (rhEPO), a recombinant erythropoietin, is crucial for sustaining erythropoiesis and is utilized in anemia research [1].
T9756	AZD-9574		PARP
	AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.		PARP
T8806	Fluzoparib	HS10160,SHR3162	PARP
	Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.		PARP
T2276	RI-1	RI1,RAD51 inhibitor 1	DNA/RNA Synthesis
	RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).		DNA/RNA Synthesis
T26408	A 21960	Ethyl 2-chloroacetoacetate,A21960,A-21960
	A 21960 (Ethyl 2-chloroacetoacetate) inhibits synapse formation between resolvase and two directly repeated res sites, blocks site-specific recombination reactions, and can be used to study bacterial infections.
T2628	RI-2		DNA/RNA Synthesis
	RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.		DNA/RNA Synthesis
T8880	PFM01		Others
	PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).		Others
T63228	Simmiparib	SMOCL-9112	Apoptosis , PARP
	Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...		Apoptosis , PARP
T6960L	PU-H71 HCl	PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl	HSP , DNA/RNA Synthesis
	PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of maligna...		HSP , DNA/RNA Synthesis
T68398	MI-223
	MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
T30492	BMS 186318	BMS-186318,BMS186318
	BMS 186318 is a human immunodeficiency virus (HIV) protease inhibitor designed to examine the possibility of developing resistance when two protease inhibitors are used together in recombination.
T26407	A 20832	A-20832,A20832
	A-20832 inhibits resolvase-promoted site-specific recombination postsynaptically at strand cleavage. It does not inhibit resolvase binding to res, as measured by filter binding, or synapse formation. DNase I analysis in ...
T78970	Antitumor agent-96		Apoptosis
	"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the endonuclease functions of MRE11, thereby inducing apoptosis i...		Apoptosis
T36703	CAY10760
	CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing Bx...
T28536	RI(dl)-2 TFA	RI(dl)-2
	RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM which also inhibits homologous recombination(HR) activity in human cells with IC50 of 3.0 μM[1].
T38093	NT1-O12B	NT1-O12B
	NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorpo...
T72560	Antitumor agent-81
	Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Addi...
T81640	NSC15520
	NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the he...
T74501	NHEJ inhibitor-1
	NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt(II) complex, mitigates non-homologous end joining (NHEJ)/homologous recombination (HR)-related double strand break (DSB) repairs, combating Cisplatin resistance in non-s...