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RI(dl)-2 TFA

Catalog No. T28536 CAS 1902146-75-1

Synonyms: RI(dl)-2

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM which also inhibits homologous recombination(HR) activity in human cells with IC50 of 3.0 μM[1].

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RI(dl)-2 TFA, CAS 1902146-75-1

Pack Size	Availability	Price/USD
25 mg	Inquiry	$ 1,350.00
50 mg	Inquiry	$ 1,760.00
100 mg	Inquiry	$ 2,680.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM which also inhibits homologous recombination(HR) activity in human cells with IC50 of 3.0 μM[1].
In vitro	RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA) [1]. When challenged with high salt concentrations, RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes[1].

Synonyms	RI(dl)-2
Molecular Weight	287.36
Formula	C19H17N3
CAS No.	1902146-75-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mongraw-Chaffin M, LaCroix AZ, Sears DD, Garcia L, Phillips LS, Salmoirago-Blotcher E, Zaslavsky O, Anderson CA. A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative. Metabolism. 2017 May;70:116-124. doi: 10.1016/j.metabol.2017.02.010. Epub 2017 Feb 16. PubMed PMID: 28403935; PubMed Central PMCID: PMC5402725. 2. Kim JH, Lee SM, Son YK, Kim SE, An WS. Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication. Kidney Res Clin Pract. 2017 Mar;36(1):58-67. doi: 10.23876/j.krcp.2017.36.1.58. Epub 2017 Mar 31. PubMed PMID: 28392998; PubMed Central PMCID: PMC5331976. 3. Castillo JJ, Jurczyszyn A, Brozova L, Crusoe E, Czepiel J, Davila J, Dispenzieri A, Eveillard M, Fiala MA, Ghobrial IM, Gozzetti A, Gustine JN, Hajek R, Hungria V, Jarkovsky J, Jayabalan D, Laubach JP, Lewicka B, Maisnar V, Manasanch EE, Moreau P, Morgan EA, Nahi H, Niesvizky R, Paba-Prada C, Pika T, Pour L, Reagan JL, Richardson PG, Shah J, Spicka I, Vij R, Waszczuk-Gajda A, Gertz MA. IgM Myeloma: A Multicenter Retrospective Study of 134 Patients. Am J Hematol. 2017 Apr 6. doi: 10.1002/ajh.24753. [Epub ahead of print] PubMed PMID: 28383205. 4. Yuan Y, Yang X, Gong D, Liu F, Hu W, Cai W, Huang J, Yang M. Investigation for terminal reflection optical fiber SPR glucose sensor and glucose sensitive membrane with immobilized GODs. Opt Express. 2017 Feb 20;25(4):3884-3898. doi: 10.1364/OE.25.003884. PubMed PMID: 28241599.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RI(dl)-2 TFA 1902146-75-1 RI(dl)-2 RI(dl)2 TFA RI(dl) 2 TFA inhibitor inhibit

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