p110δ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16422	P110δ-IN-1	PWT-143	PI3K
	P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).		PI3K
T28416	PIK-108	PIK 108,PIK108	PI3K
	PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).		PI3K
T13386	Zandelisib		PI3K
	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.		PI3K
T2297	PIK-294	PIK294	PI3K
	PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).		PI3K
T2083	PI-3065	PI3065	DNA-PK , PI3K , mTOR
	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.		DNA-PK , PI3K , mTOR
T1894	Idelalisib	GS-1101,CAL-101	PI3K , Autophagy
	Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/γ.		PI3K , Autophagy
T8651	CAL-101	(S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib	PI3K
	CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than...		PI3K
T15592	IPI-3063		PI3K
	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).		PI3K
T1827	Buparlisib	BKM120,NVP-BKM120	Apoptosis , PI3K
	Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).		Apoptosis , PI3K
T6938	PF-4989216	PF 4989216	Apoptosis , PI3K
	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.		Apoptosis , PI3K
T24873	TGX-115	TGX 115	PI3K
	TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3...		PI3K
T2235	Dactolisib	BEZ235,NVP-BEZ235	ATM/ATR , PI3K , mTOR , Autophagy
	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).		ATM/ATR , PI3K , mTOR , Autophagy
T3348	PIK-293	PIK293	PI3K
	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.		PI3K
T6143	PI-103	PI103,PI 103	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T2073	GSK2636771	GSK 2636771,GSK-2636771	PI3K
	GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.		PI3K
T1988	Duvelisib	INK1197,IPI-145	PI3K
	Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic a...		PI3K
T7014	Voxtalisib	XL765,SAR245409	DNA-PK , PI3K , mTOR
	Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.		DNA-PK , PI3K , mTOR
T2682	Acalisib	GS-9820,CAL-120	PI3K
	Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.		PI3K
T16908	Sonolisib	PX-866	PI3K
	Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).		PI3K
T16365	Buparlisib Hydrochloride	NVP-BKM120 Hydrochloride,BKM120 Hydrochloride	Others
	Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively).		Others