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GSK2636771

Catalog No. T2073 CAS 1372540-25-4

Synonyms: GSK 2636771, GSK-2636771

GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GSK2636771, CAS 1372540-25-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 52.00
5 mg	In stock	$ 81.00
10 mg	In stock	$ 153.00
25 mg	In stock	$ 267.00
50 mg	In stock	$ 378.00
100 mg	In stock	$ 576.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Purity: 98.58%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.
Targets&IC50	PI3Kβ:5.2 nM
Cell Research	Cells are plated in 96-well microtiter plates at densities ranging from 1,500 to 15,000 cells/well, optimized for untreated control cells to be 80-90% confluent at the endpoint of the experiment. After 24 h, cells are treated with serial dilutions (100pM to 10μM) of GSK2636771. Cell viability is assessed after 72 h of treatment by incubation with CellTiter Blue for 1.5 h. The drug concentration requires for survival of 50% of cells relative to untreated cells (surviving fraction 50, SF50) is determined using GraphPad Prism version 5.0d. Cell lines that fails to achieve the SF50 to a given drug are nominally assigned as the highest concentration screened (i.e. 10μM). At least three independent experiments in triplicate per cell line targeted drug are performed. Association between a mutation and response to a targeted agent is determined using a Fisher’s exact test (GraphPad Prism), and a two-tailed P value <0.05 is considered statistically significant. (Only for Reference)

Synonyms	GSK 2636771, GSK-2636771
Molecular Weight	433.42
Formula	C22H22F3N3O3
CAS No.	1372540-25-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: <1 mg/mL

DMSO: 27 mg/mL (62.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Macauley D, et al. Drugs Fut, 2012, 37(6), 451. 2. Weigelt B, et al. Clin Cancer Res. 2013, 19(13), 3533-3544.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Glycolysis Compound Library Antioxidant Compound Library Reprogramming Compound Library Angiogenesis related Compound Library Inhibitor Library Autophagy Compound Library Bioactive Compound Library Oxidation-Reduction Compound Library Metabolism Compound Library

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Related compounds with same targets

Sennidin A Sennidin B AZD3458 PI3kδ inhibitor 1 Isoangustone A PI3K/mTOR Inhibitor-1 PI3Kdelta inhibitor 1 α-Solanine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK2636771 1372540-25-4 PI3K/Akt/mTOR signaling PI3K Inhibitor Phosphoinositide 3-kinase inhibit GSK 2636771 GSK-2636771 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.