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PIK-108

Catalog No. T28416   CAS 901398-68-3
Synonyms: PIK 108, PIK108

PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).

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PIK-108 Chemical Structure
PIK-108, CAS 901398-68-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 68.00
5 mg In stock $ 197.00
10 mg In stock $ 322.00
25 mg In stock $ 547.00
50 mg In stock $ 788.00
100 mg In stock $ 1,080.00
1 mL * 10 mM (in DMSO) In stock $ 226.00
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Purity: 99.4%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
Synonyms PIK 108, PIK108
Molecular Weight 364.44
Formula C22H24N2O3
CAS No. 901398-68-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (123.48 mM), sonification is recommended.

TargetMolReferences and Literature

1. Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Rommé B, El-Ahmad Y, Carry JC et al.. (2012) Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. J. Med. Chem., 55 (10): 4788-805. [PMID:22524426]

Related compound libraries

This product is contained In the following compound libraries:
Anti-Ovarian Cancer Compound Library Anti-Lung Cancer Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Obesity Compound Library Angiogenesis related Compound Library Oxidation-Reduction Compound Library Glycolysis Compound Library Inhibitor Library

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PIK-108 901398-68-3 PI3K/Akt/mTOR signaling PI3K p110β Inhibitor p110δ PIK 108 PIK108 Phosphoinositide 3-kinase inhibit inhibitor

 

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