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IPI-3063

Catalog No. T15592   CAS 1425043-73-7

IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).

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IPI-3063 Chemical Structure
IPI-3063, CAS 1425043-73-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 66.00
2 mg In stock $ 97.00
5 mg In stock $ 178.00
10 mg In stock $ 297.00
25 mg In stock $ 597.00
50 mg In stock $ 849.00
100 mg In stock $ 1,130.00
1 mL * 10 mM (in DMSO) In stock $ 193.00
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Purity: 99.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
Targets&IC50 p110α:1170 nM, p110γ:2187 nM, p110δ:2.5 nM, p110β:1508 nM
In vitro IPI-3063 is a p110δ selective compound with an IC50=0.1?nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very effective in reducing p-AKT (significant effect at 1?nM) and it also decreases p-ERK1/2 with a significant effect at 10?nM. IPI-3063 is very effective, achieving a significant decrease in B cell survival when present at 10?nM and it also inhibits p110α, p110β, and p110γ (IC50s: 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively). IPI-3063 effectively decreases mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1.
Molecular Weight 455.51
Formula C25H25N7O2
CAS No. 1425043-73-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (182.94 mM)

TargetMolReferences and Literature

1. Chiu H, et al. The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. Front Immunol. 2017 Jun 30;8:747.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Pancreatic Cancer Compound Library Glycolysis Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library Anti-Prostate Cancer Compound Library Bioactive Compound Library Neuronal Differentiation Compound Library Metabolism Compound Library

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Related compounds with same targets
PI3Kγ inhibitor 2 VS-5584 Desmethylglycitein IHMT-PI3Kδ-372 S-isomer PITCOIN4 GSK2292767 Samotolisib PI3Kδ-IN-18

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Keywords

IPI-3063 1425043-73-7 PI3K/Akt/mTOR signaling PI3K Inhibitor Phosphoinositide 3-kinase inhibit IPI3063 IPI 3063 inhibitor

 

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