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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1985 | WHI-P154 | Jak3 inhibitor ii | Apoptosis , EGFR , VEGFR , JAK , Src |
WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor. | |||
T2032 | WHI-P180 | Janex 3 | EGFR , VEGFR , c-RET , CDK |
WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively. | |||
T35528 | TD52 | Apoptosis , Phosphatase , Akt | |
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. | |||
T8431 | JCN037 | EGFR | |
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively). | |||
TL0016 | Sulforaphene | Apoptosis , ERK , EGFR , NF-κB | |
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EG... | |||
T35528L | TD52 dihydrochloride | TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl | Others |
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali... | |||
T11157L | EGFR-IN-1 hydrochloride | EGFR | |
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride exhibits potent antitumor and antiproliferative activity... | |||
T72818 | Dosimertinib-d | ||
Dosimertinib-d3-d3 is a potent, orally active inhibitor of EGFR, known to reduce the expression of p-EGFR and p-ERK proteins, thereby exhibiting antiproliferative and anti-tumor effects. It holds promise for research int... | |||
T72788 | EGFR/C797S-IN-1 | ||
EGFR/C797S-IN-1 is a potent inhibitor targeting the EGFR-C797S mutation, demonstrated by its IC 50 value of 0.128 µM. This compound exhibits significant anti-proliferative and anti-tumor effects by inhibiting p-EGFR expr... | |||
T74833 | EGFR T790M/L858R-IN-2 | ||
EGFRT790M/L858R-IN-2 is a potent, selective inhibitor of EGFRT790M/L858R, exhibiting IC50 values of 3.5 nM for EGFRT790M/L858R and 1290 nM for EGFR WT. This compound effectively decreases the expression of p-EGFR, P-AKT,... | |||
T35897 | ASK120067 | ||
ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]... | |||
T36648 | Tucatinib hemiethanolate | ||
Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-f... |