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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6451 | Clodronic acid disodium salt | Loron,Clodronate Disodium,Lodronate | Others |
Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. | |||
T7437 | 3-(3-Hydroxyphenyl)propionic Acid | m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid | Others , Endogenous Metabolite |
3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) is one of the major metabolites of ingested caffeic acid.it inhibited osteoclastogenesis and bone osteoclastic resorptive activity. | |||
TN3209 | 3′,4′,7-Trihydroxyflavone | ATPase , Others , p38 MAPK , NF-κB | |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclasto... | |||
T10927 | Cyt-PTPε Inhibitor-1 | Cyt-PTP|A Inhibitor-1 | Phosphatase , Src |
Cyt-PTPε Inhibitor-1 (A Inhibitor-1) is an inhibitor of cytosolic protein tyrosine phosphatase ε. Cyt-PTPε Inhibitor-1 blocks the dephosphorylation of c-Src and exhibits anti-osteoclastic activity. | |||
T61531 | NFATc1-IN-1 | RANKL/RANK | |
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuc... | |||
T4237 | Rubiadin-1-methyl ether | Rubiadin 1-methyl ether | Anti-infection , NF-κB |
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu... | |||
T69550 | NS-3736 | ||
NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption. | |||
T26512 | ABD-295 | ||
ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in ... | |||
T31382 | Deoxypyridinoline | Lysylpyridinoline | |
Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclast... | |||
T70062 | Osteoprotegerin | ||
Osteoprotegerin is a soluble secreted member of the tumor necrosis factor receptor superfamily, inhibiting osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, leading... | |||
TN1536 | Curculigoside B | Others | |
Curculigoside B shows antioxidative and antiosteoporotic activities, it can decrease area of bone resorption pit, osteoclastic formation and TRAP activity. | |||
TN3754 | Dalbergiphenol | Others | |
Dalbergiphenol shows antiosteoporotic activity, dalbergiphenol treatment can effectively prevent OVX-induced increase in bone loss and decrease in bone strength possibly by increasing osteoblastic activities and by decre... | |||
T35826 | PKC fragment (530-558) | ||
PKC fragment (530-558) is a peptide fragment of protein kinase C (PKC) and is a potent PKC activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption. | |||
T81592 | Osteostatin | PTHrP (107–111) | |
Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone e... |