notch-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16341	Notch inhibitor 1		Others
	Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.		Others
T19483	Notch 1 TFA		Others
	Notch 1 TFA encodes a member of the NOTCH family of proteins.		Others
T6861	IMR-1		Gamma-secretase
	IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.		Gamma-secretase
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid	Compound W	Gamma-secretase
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).		Gamma-secretase
T6474	Divalproex Sodium	Valproate semisodium,Epival	HDAC
	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...		HDAC
TP1540	Jagged-1 （188-204）	Jagged-1 188-204	Gamma-secretase
	Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay...		Gamma-secretase
T3633	Crenigacestat	LY3039478	Gamma-secretase
	Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...		Gamma-secretase
T35566	RBPJ Inhibitor-1	RIN1	Gamma-secretase
	RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation[1].		Gamma-secretase
T3540	IMR-1A		Gamma-secretase , Drug Metabolite
	IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.		Gamma-secretase , Drug Metabolite
T3521	γ-Secretase-IN-1	Compound E	Beta Amyloid , Gamma-secretase
	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.		Beta Amyloid , Gamma-secretase
T2842	Tangeretin	NSC53909,Tangeritin,NSC618905	Apoptosis , Gamma-secretase
	Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notc...		Apoptosis , Gamma-secretase
T24159	IHR-1	IHR 1	Smo
	IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.		Smo
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base)	Jagged-1 (188-204) TFA	Gamma-secretase
	Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing sub...		Gamma-secretase
TWS2045	Bruceine D		Apoptosis , Antiviral , Gamma-secretase , Parasite
	1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW...		Apoptosis , Antiviral , Gamma-secretase , Parasite
T76023	Jagged-1 (188-204) (TFA)
	Jagged-1 (188-204) TFA, a fragment of the Jagged-1 (JAG-1) protein, acts as a Notch agonist. This compound is significantly present in both cultured and primary multiple myeloma (MM) cells, where JAG-1 facilitates the ma...
T80615	Enoticumab	REGN421
	Enoticumab (REGN421, SAR153192) is an IgG1κ antibody that specifically targets human Delta-like ligand 4 (Dll4), which serves as a crucial component of the Notch signaling pathway and regulates the uptake of fatty acids ...