immunology — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10777	CG347B		HDAC
	CG347B is a selective inhibitor of HDAC6.		HDAC
T9210	CD73-IN-4		CD73
	CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor		CD73
T60012	HS-243		IRAK , MAPK , CDK
	HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.		IRAK , MAPK , CDK
T22418	S-99		Others
	S-99 is a high purity chemical that targets ASK and is important for Immunology, Inflammation, Cancer research.		Others
T22115	SM-7368		NF-κB
	The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.		NF-κB
T62110	MK2-IN-4
	MK2-IN-4 is a MAPKAPK2 (MK2) inhibitor (IC50: 45 nM). MK2-IN-4 can be used in cancer, inflammation and immunology studies.
T78294	Tavolixizumab	MEDI 0562,Tavolimab
	Tavolixizumab (also known as MEDI 0562 and Tavolimab) is a human monoclonal antibody targeting TNFRSF4 (TNF receptor superfamily member 4), utilized in cancer immunology studies [1].
T78672	I-287
	I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors. It has been shown to attenuate Complete Freund's adjuvant-i...
T63418	GSK040
	GSK040, a potent and highly selective inhibitor of BET BD2, exhibits a pIC50 of 8.3, demonstrating over 5000-fold selectivity against BET BD1 (pIC50=4.6). This compound is primarily utilized in oncology and immunology re...
T79823	DGKα-IN-4
	DGKα-IN-4 (example 432), an inhibitor of DGKα with an IC50 value of 0.1 nM. This compound notably potentiates the anti-tumor efficacy of anti-PD-1 therapy through augmentation of T cell proliferation and function. Additi...
T72684	TLR7/8 agonist 7
	TLR7/8 agonist 7, a compound that functions as a TLR7/8 agonist, plays a pivotal role in activating various immune cells and is instrumental in the synthesis of immune-stimulating antibody conjugate (ISAC) molecules. Thi...
T79258	SEH inhibitor-16		Epoxide Hydrolase
	sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM. It diminishes inflammatory damage associated with cerulein-induced acute pancreatitis (AP) in mice, making it suitable for i...		Epoxide Hydrolase
T75874	TcY-NH2 TFA
	tcY-NH2 (trans-Cinnamoyl)-YPGKF-NH2) TFA is a selective PAR4 antagonist peptide with potent properties. It effectively inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This compound find...
T80599	Dectrekumab	QAX576
	Dectrekumab (QAX576), a humanized monoclonal antibody targeting IL-13, significantly reduces intraepithelial esophageal eosinophil counts and normalizes dysregulated esophageal disease-related transcripts in Eosinophilic...
T79822	DGKα-IN-3
	DGKα-IN-3 (example 25), with an IC50 of 283 nM, is a selective DGKα inhibitor that augments anti-PD-1's anti-tumor activity by promoting T cell proliferation and function, showing promise for cancer and immunology resear...
T78795	IDO1/TDO-IN-6		Indoleamine 2,3-Dioxygenase (IDO)
	IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO. The compound further demonstrates Ki values of 1.9 μM for IDO1 and 3.1 μM for TDO, m...		Indoleamine 2,3-Dioxygenase (IDO)
T36421	Immuno-Oncology Screening Library
	The Immuno-Oncology Screening Library consists of 2 plates and contains more than 90 cancer and immunology-associated compounds in a 96-well Matrix tube rack format as 10 mM stock solutions in DMSO. This library include...
TP2280	Ovalbumin (324-338) [Gallus gallus]/[Coturnix coturnix]		Others
	Ovalbumin is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin is an important protein in several different areas of research, including general studies of protein structure and proper...		Others
T60292	Ibuprofen sodium
	Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective inhibitor of COX-1 (IC 50 = 13 μM). Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroid...
T81592	Osteostatin	PTHrP (107–111)
	Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone e...