hematopoiesis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T41256	SP-96		Aurora Kinase
	SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negati...		Aurora Kinase
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T2562	Eltrombopag	SB-497115,SB-497115-GR	Thrombin
	Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110).		Thrombin
T6825	Eltrombopag Olamine	Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR	Thrombin
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrom...		Thrombin
T9026	MEISi-2	Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide	Others
	MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.		Others
T5862	Ezatiostat TFA	TER199(free base),Ezatiostat TFA (free base),Ezatiostat,TLK199	GST
	Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.		GST
T21608L	β-Interleukin I (163-171), human Acetate	β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)	Others
	β-Interleukin I (163-171), human Acetateis a peptide that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.		Others
T37603L	Osteogenic Growth Peptide (10-14) acetate	Osteogenic Growth Peptide (10-14) acetate(105250-85-9 Free base)	Src
	Osteogenic Growth Peptide (10-14) acetate (Osteogenic Growth Peptide) is a Src inhibitor and an effective mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acetate is responsible...		Src
T4042	Talabostat mesylate	Val-boroPro,PT100	Proteasome , DPP-4
	Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the producti...		Proteasome , DPP-4
T4687	Ro5-3335	CBFβ-Runx1 inhibitor II,Ro 5-3335	DNA/RNA Synthesis
	Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation ...		DNA/RNA Synthesis
T1040	Vitamin B12	Cyanocobalamin,Cobalamin	Endogenous Metabolite
	Cyanocobalamin is a cobalt-containing coordination compound generated by intestinal microbes and a natural water-soluble vitamin of the B-complex family that must combine with Intrinsic Factor for absorption by the intes...		Endogenous Metabolite
T69089	Trimethoprim sulfate
	Trimethoprim sulfate is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is poten...
T77993	Goralatide acetate
	Goralatide, a natural tetrapeptide, acts as a physiological regulator of hematopoiesis and has been shown to inhibit the proliferation of primitive hematopoietic cells [1].
T81077	Substance P(1-4)
	Substance P(1-4) acts as a potent antagonist of neurokinin receptors (NK-R) and regulates normal hematopoiesis, additionally inhibiting the formation of endogenous erythroid colonies (EEC) [1].
T82060	Interleukin-6 fragment (human)
	Interleukin-6 Fragment (human) is a pleiotropic cytokine originating from both lymphocytes and non-lymphocytes, encoded by a gene on human chromosome 7 spanning roughly 5 kilobases. This fragment shows promise for use in...
T71313	BVB-808
	BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative...
T37079	VEGFR2 Kinase Inhibitor II
	Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms...