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Ezatiostat TFA

Catalog No. T5862   CAS T5862
Synonyms: TER199(free base), Ezatiostat TFA (free base), Ezatiostat, TLK199

Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.

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Ezatiostat TFA Chemical Structure
Ezatiostat TFA, CAS T5862
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 60.00
10 mg In stock $ 102.00
25 mg In stock $ 233.00
50 mg In stock $ 308.00
100 mg In stock $ 477.00
1 mL * 10 mM (in DMSO) In stock $ 116.00
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Purity: 98.74%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.
In vitro Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity (Ki = 400 nM) with minimal effect on the related GSTα and -μ families (Kis range from 20-75 μM)[1].
Synonyms TER199(free base), Ezatiostat TFA (free base), Ezatiostat, TLK199
Molecular Weight 643.67
Formula C29H36F3N3O8S
CAS No. T5862

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (47.2 mM)

TargetMolReferences and Literature

1. Ruscoe J E , Rosario L A , Wang T , et al. Pharmacologic or Genetic Manipulation of Glutathione S-Transferase P1–1 (GSTπ) Influences Cell Proliferation Pathways[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(1):339-345. 2. Galili N , Tamayo P , Botvinnik O B , et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome[J]. Journal of Hematology & Oncology, 2012, 5(1):20.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Keywords

Ezatiostat TFA T5862 oxidation-reduction GST TER199(free base) TLK 199 Ezatiostat TFA (free base) TLK-199 Ezatiostat TLK199 inhibitor inhibit

 

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