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Ezatiostat TFA

Catalog No. T5862 CAS T5862

Synonyms: TER199(free base), Ezatiostat TFA (free base), Ezatiostat, TLK199

Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.

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Ezatiostat TFA, CAS T5862

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 60.00
10 mg	In stock	$ 102.00
25 mg	In stock	$ 233.00
50 mg	In stock	$ 308.00
100 mg	In stock	$ 477.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 98.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.
In vitro	Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity (Ki = 400 nM) with minimal effect on the related GSTα and -μ families (Kis range from 20-75 μM)[1].

Synonyms	TER199(free base), Ezatiostat TFA (free base), Ezatiostat, TLK199
Molecular Weight	643.67
Formula	C29H36F3N3O8S
CAS No.	T5862

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (47.2 mM)

References and Literature

1. Ruscoe J E , Rosario L A , Wang T , et al. Pharmacologic or Genetic Manipulation of Glutathione S-Transferase P1–1 (GSTπ) Influences Cell Proliferation Pathways[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(1):339-345. 2. Galili N , Tamayo P , Botvinnik O B , et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome[J]. Journal of Hematology & Oncology, 2012, 5(1):20.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ezatiostat TFA T5862 oxidation-reduction GST TER199(free base) TLK 199 Ezatiostat TFA (free base) TLK-199 Ezatiostat TLK199 inhibitor inhibit

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