genotoxicity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2S2109	Skimmianine	beta-Fagarine,Skimmianin,Chloroxylonine,Skimmiamine	Others
	1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.		Others
T38311	(S)-3-Thienylglycine		Others
	(S)-3-Thienylglycine is a thiophene derivative and can be used to investigate the genotoxicity of the similar structures with thiophene derivatives.		Others
T4822	N-Acetylglycine	Acetamidoacetic acid,Aceturic acid	Others , Endogenous Metabolite
	N-Acetylglycine (Aceturic acid), a minor component found in a variety of foods, exhibits neither genotoxicity nor acute toxicity. It is utilized in the biological study of peptidomimetics.		Others , Endogenous Metabolite
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
TN1962	Myricetin 3-O-galactoside	Myricetin 3-O-beta-D-galactopyranoside	NOS , Xanthine Oxidase
	Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) can inhibit xanthine oxidase (xanthine oxidase; XO) activity, lipid peroxidation and scavenging free radicals. Myricetin 3-O-galactoside has many effects...		NOS , Xanthine Oxidase
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
T40382	Dibromoacetaldehyde
	Dibromoacetaldehyde, a halogenated byproduct found in drinking water, exhibits genotoxicity.
T16160	Musk tibetene	Musk tibetine	Others
	Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity.		Others
T9791	Mequindox
	Mequindox is an antimicrobial agent [1]. Mequindox, as an inhibitor of DNA synthesis, induces genotoxicity and carcinogenicity in mice [2].
T63495	CYP2C1/CYP2C19-IN-2
	CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.
T79212	MTOR inhibitor-12		mTOR
	mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central nervous system (CNS) diseases [1].		mTOR
TN4841	Ptaquiloside
	Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium.
T63496	CYP2C9/CYP2C19-IN-1
	CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.
T63025	Antitubercular agent-26
	Antitubercular agent-26 (Compound 32) is an orally active antitubercular agent that acts on M. tuberculosisH37Rv cells (IC50: 0.50 μM extracellularly and 0.51 μM intracellularly). 26 has good metabolic stability, low ris...
T36001	4-hydroperoxy 2-Nonenal
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress. 4-HNE exhibits var...
T70782	PF-05139962
	PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respec...
TN4084	Fumitremorgin B		Antifection
	Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M ph...		Antifection
T35646	4-oxo-2-Nonenal	4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, ...