esterases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3990	AA26-9		Phospholipase , Serine Protease
	AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.		Phospholipase , Serine Protease
T24047	Etilevodopa hydrochloride	Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester	Others , Dopamine Receptor , Drug Metabolite
	Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.		Others , Dopamine Receptor , Drug Metabolite
T3359	Aprotinin	Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others , Serine Protease , Influenza Virus , Proteasome
	Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...		Others , Serine Protease , Influenza Virus , Proteasome
T15378L	Gemcitabine elaidate hydrochloride	CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride	Others
	Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. In contrast to gemcitabine, G...		Others
T14319	Aripiprazole Lauroxil		Dopamine Receptor , 5-HT Receptor
	Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic. Aripiprazole lauroxil is cleaved by esterases in vivo to N-hydroxymethyl aripiprazole (lauric acid), ...		Dopamine Receptor , 5-HT Receptor
T14048	5-CFDA	5-Carboxyfluorescein diacetate	Others
	5-CFDA (5-Carboxyfluorescein diacetate)(5-Carboxyfluorescein diacetate) is membrane-permeant. It can be loaded into cells via incubation and hydrolyzed by intracellular esterases to 5-carboxyfluorescein that is used for ...		Others
T15082	DDAO		Others
	DDAO is a promising near-infrared (NIR) red fluorescent probe with long emission wavelength (λem = 656 nm) and tunable excitation wavelength (600-650 nm). It can de desiged for detection of the activities of different en...		Others
T3934	Isavuconazonium sulfate		Antifungal
	Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh...		Antifungal
T68889	Esterastin
	Esterastin is an Inhibitor of esterases.
T25755	Lorajmine	Lorajmina
	Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.
T20518	Fosinoprilat	SQ-27,519,Fosinopril diacid,SQ 27,519,SQ27,519
	Fosinoprilat, an active phosphinic acid metabolite of prodrug fosenopril, is activated by esterases in vivo. Fosinoprilat binds zinc with phosphinic acid group.
T15255	Etilevodopa	Levodopa ethyl ester,L-DOPA ethyl ester	Others
	Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levo...		Others
T4574L	Sacubitril sodium	AHU377,AHU-377,LCZ696,AHU 377
	Sacubitril is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases.
T35612	CytoCalcein™ Violet 500
	CytoCalcein Violet 500 is a fluorogenic dye used to assess cell viability. It is a cell-permeable dye that, upon entering cells, is cleaved by intracellular esterases. CytoCalcein Violet 500 is retained by living cells...
T26611	AM7499	AM 7499,AM-7499
	AM7499 is a non-selective cannabinoid receptor agonist with remarkably high in vitro and in vivo potency. It is readily hydrolysed by plasma esterases and to be less prone to deposition in bodily fat than existing classi...
T70621	Cefditoren Pivoxil HCl
	Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intest...
T35611	CytoCalcein™ Violet 450
	CytoCalcein Violet 450 is a fluorogenic dye used to assess cell viability. It is a cell-permeable dye that, upon entering cells, is cleaved by intracellular esterases. CytoCalcein Violet 450 is retained by living cells...
T37290	Resolvin D3 methyl ester
	Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cle...
T36369	3,6-diacetoxy Phthalonitrile
	3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells. It rapidly crosses cell membranes and is cleaved by cytosolic esterases to form the fluorescent pH in...
T38352	Ebelactone A
	Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08...