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AA26-9

🥰Excellent
Catalog No. T3990Cas No. 1312782-34-5

AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.

AA26-9

AA26-9

🥰Excellent
Purity: 99.88%
Catalog No. T3990Cas No. 1312782-34-5
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31In StockIn Stock
2 mg$44In StockIn Stock
5 mg$72In StockIn Stock
10 mg$122In StockIn Stock
25 mg$222In StockIn Stock
50 mg$369In StockIn Stock
100 mg$549In StockIn Stock
1 mL x 10 mM (in DMSO)$79In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.88%
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Product Introduction

Bioactivity
Description
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
In vitro
AA26-9 inhibits enzymes originated from diverse functional subclasses of serine hydrolases, including peptidases (APEH, CTSA, PRCP), thioesterases (LYPLA1/2), lipases/phospholipases (AADACL1, ESD, ABHD6, PAFAH2, FAAH, LYPLA3), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.
Cell Research
AA26-9 is prepared in DMSO. Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP[1].
Chemical Properties
Molecular Weight166.18
FormulaC7H10N4O
Cas No.1312782-34-5
SmilesO=C(N1CCCC1)n1ccnn1
Relative Density.1.42 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (330.97 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.04 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.0176 mL30.0879 mL60.1757 mL300.8786 mL
5 mM1.2035 mL6.0176 mL12.0351 mL60.1757 mL
10 mM0.6018 mL3.0088 mL6.0176 mL30.0879 mL
20 mM0.3009 mL1.5044 mL3.0088 mL15.0439 mL
50 mM0.1204 mL0.6018 mL1.2035 mL6.0176 mL
100 mM0.0602 mL0.3009 mL0.6018 mL3.0088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

thioesterasesSerineProteaseSerine Proteaseserine hydrolaseserinePhospholipasepeptidaseslipasesInhibitorinhibitesterasescellamidasesAA26-9AA-26-9AA269AA26 9
Related Tags: buy AA26-9 | purchase AA26-9 | AA26-9 cost | order AA26-9 | AA26-9 chemical structure | AA26-9 in vitro | AA26-9 formula | AA26-9 molecular weight
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