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Search Results for " epigenetic "

20

Compounds

Cat No. Product Name Synonyms Targets
T72013 Epigenetic Multiple Ligand
Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing e...
T82458 Epigenetic factor-IN-1 Sirtuin
Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7. It is utilized in the study of liver cancer [1].
T15424 GSK1379725A Epigenetic Reader Domain
GSK1379725A is a selective BPTF ligand (Kd: 2.8 uM). It also shows no binding activity for Brd4.
T11925 M‑89 Epigenetic Reader Domain , Histone Methyltransferase
M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin binding. This compound holds potential for treating MLL leukemia...
T2072 BET bromodomain inhibitor Epigenetic Reader Domain
BET bromodomain inhibitor is a potent BET inhibitor.
T5440 Dbet57 Epigenetic Reader Domain
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2
T4495 DBET1 Epigenetic Reader Domain
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
T6668 SGC-CBP30 Epigenetic Reader Domain , Histone Acetyltransferase
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T5130 DBET6 Apoptosis , Epigenetic Reader Domain
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T6783 BI-7273 Epigenetic Reader Domain
BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
TQ0083 NI-57 Epigenetic Reader Domain
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.
TQ0253 PLX51107 Epigenetic Reader Domain
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T12112 MS402 Epigenetic Reader Domain
MS402 is a novel BD1-selective BET BrD inhibitor.
TQ0069 MI-503 Epigenetic Reader Domain , Histone Methyltransferase
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
T16321 NI-42 Epigenetic Reader Domain
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele...
T9749 FHD-286 Epigenetic Reader Domain
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.
T2127 OF-1 Epigenetic Reader Domain
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T3311 GSK6853 Epigenetic Reader Domain
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
TQ0058 MI-463 Epigenetic Reader Domain , Histone Methyltransferase
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T16072 MI-538 Epigenetic Reader Domain , Histone Methyltransferase
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
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