Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 139.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 347.00 | |
25 mg | In stock | $ 625.00 | |
50 mg | In stock | $ 939.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 246.00 |
Description | MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). |
Targets&IC50 | Menin:6.5 nM(Kd), Menin-MLL:21 nM |
In vitro | Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression. |
In vivo | Treatment with MI-538 results in a pronounced, about 80%, reduction in the MV4;11 tumor volume, without causing substantial signs of toxicity reflected by less than 10% reduction of the body weight. |
Molecular Weight | 566.6 |
Formula | C27H25F3N8OS |
CAS No. | 1857417-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (167.67 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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MI-538 1857417-10-7 Chromatin/Epigenetic Epigenetic Reader Domain Histone Methyltransferase inhibit Inhibitor MI538 MI 538 inhibitor