deacetylase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2157	M344	MS 344,Histone Deacetylase Inhibitor III	HDAC
	M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.		HDAC
T3206	NKL 22	Histone Deacetylase Inhibitor IV,PAOA	HDAC
	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.		HDAC
T3193	Pimelic diphenylamide 106	Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8	HDAC
	Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs.		HDAC
T39233	SIRT7 inhibitor 97491		Sirtuin
	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.		Sirtuin
T4328	OSS_128167	SIRT6-IN-1	HBV , Sirtuin
	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).		HBV , Sirtuin
T6055	Quisinostat	JNJ-26481585	Apoptosis , HDAC , Autophagy
	Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against...		Apoptosis , HDAC , Autophagy
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T6865	Quisinostat dihydrochloride	Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis , HDAC , Autophagy
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g...		Apoptosis , HDAC , Autophagy
T38318L	Acetyl Pentapeptide-1 acetate		Histone Demethylase
	Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.		Histone Demethylase
T7691	NSC 3852		HDAC
	NSC 3852 is a potent inhibitor of histone deacetylase.		HDAC
T8508	HDAC-IN-3	GSK3117391A	HDAC
	HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.		HDAC
T3983	TMP195	TFMO 2,TMP 195	HDAC
	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.		HDAC
T2489	Ricolinostat	ACY-1215,Rocilinostat	Apoptosis , HDAC
	Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.		Apoptosis , HDAC
T69753	HDAC6 degrader 9c		HDAC
	HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.		HDAC
T79903	Sirtuin-1 inhibitor 1		Sirtuin
	Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.		Sirtuin
T3358	ITSA-1	ITSA1	HDAC
	ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.		HDAC
T8517	Belinostat	PX105684,PXD101,PXD-101	HDAC , Autophagy
	Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.		HDAC , Autophagy
T6678	Splitomicin	1-Naphthalenepropanoic Acid	Sirtuin , HDAC
	Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.		Sirtuin , HDAC
T16729	Remetinostat	SHP-141	HDAC
	Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymphoma.		HDAC
T30579	BRD4097		HDAC
	BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insulin resistance, help promote cognitive function and enhance l...		HDAC