Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Description | SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway. |
Targets&IC50 | SIRT7:325 nM |
In vitro | SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1]. Cell Proliferation Assay[1]Cell Line: Human uterine sarcoma MES-SA cells Concentration: 1, 5, 10 μM Incubation Time: 72 hours Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay[1]Cell Line: Human embryonic kidney cell line HEK293 cells Concentration: 1, 5, 10 μM Incubation Time: 24 hours Result: HEK293 cells were almost unaffected. |
In vivo | SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1]. Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]Dosage: 2 mg/kg Administration: Intraperitoneally injected; for 3 weeks, except on weekends. Result: Inhibited cancer growth in vivo. |
Molecular Weight | 285.73 |
Formula | C15H12ClN3O |
CAS No. | 1807758-81-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 500 mg/mL (1749.90 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SIRT7 inhibitor 97491 1807758-81-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin SIRT7 inhibit p53 K373/382 tumor SIRT-7 inhibitor 97491 deacetylase Apoptosis Inhibitor inhibitor