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SIRT7 inhibitor 97491

Catalog No. T39233   CAS 1807758-81-1

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.

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SIRT7 inhibitor 97491 Chemical Structure
SIRT7 inhibitor 97491, CAS 1807758-81-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 247.00
10 mg In stock $ 372.00
25 mg In stock $ 629.00
50 mg In stock $ 896.00
100 mg In stock $ 1,220.00
1 mL * 10 mM (in DMSO) In stock $ 272.00
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Purity: 99.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Targets&IC50 SIRT7:325 nM
In vitro SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1]. Cell Proliferation Assay[1]Cell Line: Human uterine sarcoma MES-SA cells Concentration: 1, 5, 10 μM Incubation Time: 72 hours Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay[1]Cell Line: Human embryonic kidney cell line HEK293 cells Concentration: 1, 5, 10 μM Incubation Time: 24 hours Result: HEK293 cells were almost unaffected.
In vivo SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1]. Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]Dosage: 2 mg/kg Administration: Intraperitoneally injected; for 3 weeks, except on weekends. Result: Inhibited cancer growth in vivo.
Molecular Weight 285.73
Formula C15H12ClN3O
CAS No. 1807758-81-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 500 mg/mL (1749.90 mM)

TargetMolReferences and Literature

1. Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Bioactive Compound Library Epigenetics Compound Library DNA Damage & Repair Compound Library Inhibitor Library Anti-Cancer Compound Library Histone Modification Compound Library

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AK-1 Ginkgolide C Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) SIRT1 activator 1 Resveratrol YM-08 MDL-811 Selisistat

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Keywords

SIRT7 inhibitor 97491 1807758-81-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin SIRT7 inhibit p53 K373/382 tumor SIRT-7 inhibitor 97491 deacetylase Apoptosis Inhibitor inhibitor

 

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