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SIRT7 inhibitor 97491

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Purity:99.79%

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COA HNMR HPLC

SIRT7 inhibitor 97491

Catalog No. T39233Cas No. 1807758-81-1

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$247	In Stock
10 mg	$372	In Stock
25 mg	$629	In Stock
50 mg	$896	In Stock
100 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
In vitro	SIRT7 inhibitor 97491 (1-10 μM) effectively reduces the proliferation of human uterine sarcoma MES-SA cells without exhibiting cytotoxic effects on HEK293 human embryonic kidney cells[1]. Specifically, when applied at concentrations of 1, 5, and 10 μM for 72 hours, it resulted in a greater than 50% decrease in proliferation of MES-SA cells at the 5 and 10 μM concentrations. Conversely, the same concentrations did not significantly affect the viability of HEK293 cells after 24 hours of exposure, indicating selective action.
In vivo	The SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) effectively suppresses tumor growth in xenograft mice[1]. Utilizing Balb/c nude mice (18-20 g; 6-8 weeks old) implanted with MES-SA cells[1], the dosage administered was 2 mg/kg via intraperitoneal injection over a three-week period, excluding weekends. The outcome was a significant inhibition of cancer growth in vivo.

Chemical Properties

Molecular Weight	285.73
Formula	C15H12ClN3O
Cas No.	1807758-81-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 500 mg/mL (1749.90 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4998 mL	17.4990 mL	34.9981 mL	174.9904 mL
5 mM	0.7000 mL	3.4998 mL	6.9996 mL	34.9981 mL
10 mM	0.3500 mL	1.7499 mL	3.4998 mL	17.4990 mL
20 mM	0.1750 mL	0.8750 mL	1.7499 mL	8.7495 mL
50 mM	0.0700 mL	0.3500 mL	0.7000 mL	3.4998 mL
100 mM	0.0350 mL	0.1750 mL	0.3500 mL	1.7499 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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