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SIRT7 inhibitor 97491

Catalog No. T39233 CAS 1807758-81-1

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.

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SIRT7 inhibitor 97491, CAS 1807758-81-1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Targets&IC50	SIRT7:325 nM
In vitro	SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1]. Cell Proliferation Assay[1]Cell Line: Human uterine sarcoma MES-SA cells Concentration: 1, 5, 10 μM Incubation Time: 72 hours Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay[1]Cell Line: Human embryonic kidney cell line HEK293 cells Concentration: 1, 5, 10 μM Incubation Time: 24 hours Result: HEK293 cells were almost unaffected.
In vivo	SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1]. Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]Dosage: 2 mg/kg Administration: Intraperitoneally injected; for 3 weeks, except on weekends. Result: Inhibited cancer growth in vivo.

Molecular Weight	285.73
Formula	C15H12ClN3O
CAS No.	1807758-81-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 500 mg/mL (1749.90 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SIRT7 inhibitor 97491 1807758-81-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin SIRT7 inhibit p53 K373/382 tumor SIRT-7 inhibitor 97491 deacetylase Apoptosis Inhibitor inhibitor

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