convulsions — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22782	FGIN-1-27		Others
	high affinity agonist of the translocator protein		Others
T11349	GABAA receptor agent 1		GABA Receptor
	GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.		GABA Receptor
T4664	ML 297	ML297	Potassium Channel
	ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, an...		Potassium Channel
T0235	Modaline sulfate		MAO , Monoamine Oxidase
	Modaline was a 2-methyl-3-piperidinopyrazine derivative found to inhibit monoamine oxidase (MAO) and showed a curative effect for the anti-depressant. Similar to other MAO inhibitors, it enhanced convulsions induced by t...		MAO , Monoamine Oxidase
T0169	Nefiracetam	DM9384,DZL-221	GABA Receptor
	Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.		GABA Receptor
T35033	Vamicamide	FK 176,FK-176,FK176	AChE
	Vamicamide (FK 176) is a novel anticholinergic compound. Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg (p.o.) or higher and inhibits cataleptic convulsions in mice at 100 mg/kg.		AChE
TN1010	Polyphyllin H		Others
	Polyphyllin H can be extracted from loblolly pine and rhizomes, has antitumor activity, and is used in studies of inflammation, fractures, and convulsions.		Others
T35033L	(S)-Vamicamide	(S)-Vamicamide (Iso-132373-81-0)	AChE
	(S)-Vamicamide is a novel anticholinergic compound.Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg or higher (p.o.) and inhibits tonic convulsions in mice at 100 mg/kg.CAS 번호13483-86-1		AChE
T37190	L-Allylglycine		Dehydrogenase , GABA Receptor
	L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ...		Dehydrogenase , GABA Receptor
T25052	Allylglycine
	Allylglycine is a glutamate decarboxylase inhibitor and a GAMMA-AMINOBUTYRIC ACID antagonist. It is used to induce convulsions in experimental animals.
T34501	Samandarine
	Samandarine is the main steroidal alkaloid secreted by the fire salamander (Salamandra salamandra). The compound is extremely toxic and causes convulsions, respiratory paralysis, and eventual death.
T71882	Pifexole
	Pifexole is the 1,2,4-oxadiazole derivative. It has a similar profile of muscle-relaxant activity in animals to that of chlorzoxazone. In rats, pifexole is reported to be seven times more potent than chlorzoxazone in inh...
T62963	Xanthine amine congener hydrochloride
	Xanthine amine congener (XAC) hydrochloride is a non-selective adenosine receptor antagonist that induces convulsions in mice.
T69144	Hexylcaine HCl
	Hexylcaine HCl also called cyclaine or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and t...
T22734	DL-AP7		Others
	DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].		Others
T25764	LY 81067	Lilly-81067,LY81067,Lilly81067,Lilly 81067,LY-81067
	LY 81067 is a new anticonvulsive compound that effectively protects against pentylenetetrazole- and picrotoxin-induced convulsions in mice. It exerts its anticonvulsant effects by binding to or near picrotoxin binding si...
T16948	Suclofenide	PB385,Neosulfalepsine	Others
	Suclofenide is a benzenesulfonamide derivative that acts as an anticonvulsant and antiepileptic agent. In preclinical models, it showed potent anticonvulsant activity against electroshock and pentylenetetrazole-induced c...		Others
TN4322	Isopulegol		ATPase , Potassium Channel , GABA Receptor
	Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GA...		ATPase , Potassium Channel , GABA Receptor
T70896	PF05020182
	PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemic...
T72246	Bicuculline methobromide	(+)-Bicuculline methobromide,d-Bicuculline methobromide,(+)-Bicuculline methobromide ; d-Bicuculline methobromide
	Bicuculline methobromide, a selective GABAA Receptor antagonist with an IC50 value of 3 μM, induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels. It is applicable in researching epilep...