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ML 297

Catalog No. T4664 CAS 1443246-62-5

Synonyms: ML297

ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ML 297, CAS 1443246-62-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 342.00
100 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 76.00

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Purity: 96.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.
Targets&IC50	GIRK1/3:914 nM, GIRK1/2:160nM, GIRK1/4:887nM

Synonyms	ML297
Molecular Weight	328.32
Formula	C17H14F2N4O
CAS No.	1443246-62-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (137.06 mM)

References and Literature

1. Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability. Neuropsychopharmacology. 2017 Aug;42(9):1800-1812. 2. Wen W, Wu W, Weaver CD, Lindsley CW. Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas. Bioorg Med Chem Lett.Br J Pharmacol. 2016 Mar;173(5):888-98. 3. Wydeven N, Marron Fernandez de Velasco E, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K. Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10755-60. 4. Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016 Mar;173(5):888-98. 5. Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.

Related compound libraries

This product is contained In the following compound libraries：

CNS-Penetrant Compound Library Covalent Inhibitor Library NO PAINS Compound Library Potassium Channel Blocker Library Anti-Cancer Compound Library Ion Channel Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

ML 297 1443246-62-5 Membrane transporter/Ion channel Potassium Channel CID 56642816 epilepsy GIRK1/2 CID56642816 ML297 VU0456810 CID-56642816 GIRK convulsions inhibit KcsA VU-0456810 VU 0456810 ML-297 Inhibitor inhibitor

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