capsaicin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1062	Capsaicin	Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,Vanilloid,(E)-Capsaicin,Zostrix	Apoptosis , TRP/TRPV Channel , Autophagy
	Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.		Apoptosis , TRP/TRPV Channel , Autophagy
T1109	(Z)-Capsaicin	Zucapsaicin,Civamide,cis-Capsaicin	TRP/TRPV Channel , HSV
	(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeutic efficacy in pain ac...		TRP/TRPV Channel , HSV
T39018	Capsaicin β-D-glucopyranoside
	Capsaicin β-D-glucopyranoside, a glucoside converted by Capsaicin, is the bioactive compound found in chili peppers responsible for their characteristic pungent flavor.
T3421	Nordihydrocapsaicin		Others
	Nordihydrocapsaicin is an analog and congener of capsaicin, belonging to the capsaicinoid class of compounds found in Capsicum chili peppers.		Others
T16014	Mavatrep	JNJ-39439335	TRP/TRPV Channel
	Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.		TRP/TRPV Channel
T23322	SB 452533		TRP/TRPV Channel
	SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).		TRP/TRPV Channel
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T39349	Vocacapsaicin hydrochloride	CA-008 hydrochloride	TRP/TRPV Channel
	Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.		TRP/TRPV Channel
TN1739	Homodihydrocapsaicin I		Others
	Homodihydrocapsaicin I is a natural product from Capsicum annuum L.		Others
T39348	Vocacapsaicin	CA-008,Vocacapsaicin
	Vocacapsaicin (CA-008), a prodrug of Capsaicin and a first-in-class non-opioid TRPV1 agonist, offers significant and enduring pain relief.
T82187	Homocapsaicin II
	Homocapsaicin II, a pungent compound, is isolable from the fruits of Capsicum annuum L [1].
T6379	AMG 517	AMG517,AMG-517	TRP/TRPV Channel
	AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.		TRP/TRPV Channel
T7177	Capsazepine		Apoptosis , TRP/TRPV Channel
	Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is ...		Apoptosis , TRP/TRPV Channel
T1356	4-Hydroxy-3-methoxybenzylamine hydrochloride	N-Vanillylamine hydrochloride	Others
	4-Hydroxy-3-methoxybenzylamine hydrochloride (N-Vanillylamine hydrochloride) is an alkaloid that is an intermediate in the biosynthesis of capsaicin. 4-Hydroxy-3-methoxybenzylamine hydrochloride is produced from vanillin...		Others
T29522L	(S)-ABT 102		TRP/TRPV Channel
	N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea is a potent TRPV1 antagonist, blocking activation of TRPV1 by capsaicin with the IC50 of 123 nM.		TRP/TRPV Channel
T7189	AMG9810		TRP/TRPV Channel
	AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).		TRP/TRPV Channel
T7102	BCTC		TRP/TRPV Channel
	BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)		TRP/TRPV Channel
T5S1389	Escin IB		5-HT Receptor , NO Synthase
	Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes...		5-HT Receptor , NO Synthase
TN2429	Capsiate		Antioxidant , TRP/TRPV Channel
	Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.		Antioxidant , TRP/TRPV Channel
T4513	Vanillyl butyl ether	4-(Butoxymethyl)-2-methoxyphenol,Butyl vanillyl ether	Others
	Vanillyl butyl ether (Butyl vanillyl ether) (VBE)is a capsaicin analogue,induce sensory irritation in humans,Vanillyl butyl ether is an alkoxy-substituted benzyl derivative mainly used as a flavoring agent.		Others