alkylation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11120	Duocarmycin TM		DNA Alkylation , Antibiotic
	Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.		DNA Alkylation , Antibiotic
T8897	2-Iodoacetamide	Iodoacetamide	Others
	Iodoacetamide, an alkylating agent, is commonly utilized for cysteine alkylation in proteomics sample preparation.		Others
T8330	BIO-013077-01		TGF-beta/Smad
	BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.		TGF-beta/Smad
T0449	Menadione	Vitamin K3	Thrombin , Endogenous Metabolite
	Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		Thrombin , Endogenous Metabolite
T0923	Busulfan	Myleran,Sulphabutin,Busulphan	Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation
	Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation...		Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation
T4580	4-Octyl itaconate		Nrf2
	4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite. 4-Octyl Itaconate activates Nrf2 via alkylation of KEAP1 and also inhibits phosphorylation of STING. 4-Octyl Itaconate is an...		Nrf2
T1488	Procarbazine hydrochloride	NSC-77213 HCl,Procarbazine HCl	DNA Alkylator/Crosslinker , DNA/RNA Synthesis
	Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba...		DNA Alkylator/Crosslinker , DNA/RNA Synthesis
T10018	1-Methyladenine		Others
	1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.		Others
T31551	Mipicoledine	DMCHOCPEN,DM-CHOC-PEN,DM CHOC PEN
	DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer.
T10973	DC41SMe		Others
	DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used fo...		Others
T11118	Duocarmycin SA		Others
	Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom...		Others
T83019	Antiproliferative agent-38
	Antiproliferative Agent-38 (COM 18), a tetracyclic compound, features a reactive ring nitrogen (likely the quinoline moiety) that resists N-alkylation. Despite its classification, it neither exhibits anti-malarial proper...
TN4505	Masticadienolic acid		Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid...		Others
T38710	JH295
	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alky...
T61061	JH295 hydrate
	JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor that inhibits cellular Nek2 by Cys22 alkylation (IC50 = 770 nM). JH295 hydrate is not active against the mitotic kinases, Cdk1,...
T79665	RUNX-IN-2		Apoptosis
	RUNX-IN-2 (Compound Conjugate 3) covalently attaches to RUNX-binding sequences, preventing RUNX proteins from associating with their targets, thereby inhibiting cancer cell proliferation and inducing p53-dependent apopto...		Apoptosis