usp7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4338	USP7/USP47 inhibitor	USP7/47 inhibitor-1	DUB
	USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.		DUB
T13268	USP7-IN-1		DUB
	USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).		DUB
T9217	USP7-IN-8	GNE-6776	DUB
	Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 (GNE-6776) has anticancer effects.		DUB
T13271	USP7-IN-6		DUB
	USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).		DUB
T13269	USP7-IN-3		DUB
	USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).		DUB
T69820	USP7-IN-4
	USP7-IN-4 is a highly potent and selective allosteric USP7 inhibitor.
T13270	USP7-IN-5		DUB
	USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).		DUB
T73136	USP7-IN-10
	USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.
T79164	USP7-IN-12
	USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].
T73234	USP7-IN-7
	USP7-IN-7, a potent USP7 inhibitor, exhibits an IC50 value of <10 nM. Demonstrating cytotoxicity against both p53-mutant and p53 wild-type blood cancer, as well as neuroblastoma cell lines at low nanomolar concentrations...
T73257	USP7-IN-9
	USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protei...
T78150	USP7-IN-10 hydrochloride
	USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39 nM [1].
T9122	XL177A		DUB
	XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.		DUB
T69819	ALM2
	ALM2 is an USP7 inhibitor.
T5461	GNE-6640		DUB
	GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23...		DUB
T6925	P005091	P5091	DUB
	P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.		DUB
T15351	FT827		DUB
	FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.		DUB
T21527	HBX 41108	HBX-41108	DUB , p53
	HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.		DUB , p53
T2424	P 22077	P22077	DUB
	P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.		DUB
T15464	HBX 19818		DUB
	HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).		DUB