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USP7-IN-8

Name: USP7-IN-8
Brand: TargetMol
SKU: T9217
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9217Cas No. 2009273-60-1

Alias GNE-6776

Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 (GNE-6776) has anticancer effects.

USP7-IN-8

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Purity: 99.31%

Catalog No. T9217Alias GNE-6776Cas No. 2009273-60-1

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$98	In Stock
10 mg	$158	In Stock
25 mg	$298	In Stock
50 mg	$433	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Batch Information

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Purity:99.31%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 (GNE-6776) has anticancer effects.
Targets&IC50	USP7:1.4 μM
Synonyms	GNE-6776

Chemical Properties

Molecular Weight	347.41
Formula	C₂₁H₂₁N₃O₂
Cas No.	2009273-60-1
Smiles	CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc(cc1)C(=O)NC
Relative Density.	1.210 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (230.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8784 mL	14.3922 mL	28.7844 mL	143.9222 mL
5 mM	0.5757 mL	2.8784 mL	5.7569 mL	28.7844 mL
10 mM	0.2878 mL	1.4392 mL	2.8784 mL	14.3922 mL
20 mM	0.1439 mL	0.7196 mL	1.4392 mL	7.1961 mL
50 mM	0.0576 mL	0.2878 mL	0.5757 mL	2.8784 mL
100 mM	0.0288 mL	0.1439 mL	0.2878 mL	1.4392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc