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USP7/USP47 inhibitor

Catalog No. T4338 CAS 1247825-37-1

Synonyms: USP7/47 inhibitor-1

USP7/USP47 inhibitor is a selective ubiquitin-specific <a href="/target/Protease" style="display: inline; color: #c13a36">Protease</a> 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

USP7/USP47 inhibitor, CAS 1247825-37-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 106.00
2 mg	In stock	$ 190.00
5 mg	In stock	$ 360.00
10 mg	In stock	$ 522.00
25 mg	In stock	$ 990.00
50 mg	In stock	$ 1,455.00
100 mg	In stock	$ 2,038.00
1 mL * 10 mM (in DMSO)	In stock	$ 360.00

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Purity: 97.98%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
Targets&IC50	USP47:1.0 μM(EC50), USP7:0.42 Μm(EC50)
In vitro	USP7/USP47 inhibitor does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM). USP7/USP47 inhibitor inhibits the growth of HCT-116 cells with an EC50 of 7.6 μM.
Kinase Assay	The cloning, expression and purification of USP21 from BL21 (DE3) bacteria are performed using standard molecular biology techniques. USP2, USP5, USP7, USP8, USP28, USP47, Ub-PLA2 (Ub-CHOP) and Ub-EKL (Ub-CHOP2) are generated. Caspase 3 and the caspase 3 substrate DEVD-Rh110 are used. Deubiquitylating enzyme, cathepsin B and 20S proteasome chymotrypsin like protease activities are measured. Caspase 3 activity is determined using a similar protocol. Briefly, dose ranges of compound (including USP7/USP47 inhibitor) are incubated with caspase 3 for 30 minutes before the addition of DEVD-Rh110 and reading on a fluorometric plate reader using excitation and emission maxima of 485 nm and 531 nm respectively. The final concentrations of caspase 3 and DEVD-Rh110 are 2 nM and 100 nM respectively

Synonyms	USP7/47 inhibitor-1
Molecular Weight	484.38
Formula	C18H11Cl2N3O3S3
CAS No.	1247825-37-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 44 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Weinstock J, et al. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.

Related compound libraries

This product is contained In the following compound libraries：

Cell Cycle Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Chromatin Modification Compound Library Anti-Aging Compound Library Ubiquitination Compound Library HIF-1 Signaling Pathway Compound Library Inhibitor Library

Related Products

Related compounds with same targets

USP8-IN-2 USP8-IN-3 USP15-IN-1 IMP-1710 HBX 41108 LDN-91946 FT827 USP7-IN-6

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

USP7/USP47 inhibitor 1247825-37-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB USP-7/USP47 inhibitor Deubiquitinase inhibit Inhibitor DUBs USP7/47 inhibitor-1 inhibitor

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