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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T60278 | Tyrosinase-IN-2 | Tyrosinase | |
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme pivotal for the catalytic step that limits the rate in melanin biosynthesis and enzymatic browning processes. This comp... | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
T4S0998 | Trifolirhizin | TNF , Tyrosinase | |
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer ... | |||
T5980 | 2-Ketoglutaric acid | Tyrosinase , Endogenous Metabolite | |
2-Ketoglutaric acid is a key molecule in the tricarboxylic acid cycle,is also connected to glutamic acid and glutamine metabolisms through the transamination reactions. | |||
T3923 | Calycosin | Cyclosin,3'-Hydroxyformononetin | Apoptosis , Tyrosinase |
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c... | |||
T3737 | 3-(2,4-Dihydroxyphenyl)propanoic acid | Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid | Tyrosinase |
3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is generated by abkar1... | |||
TMA0003 | Trans-caffeic acid | cAMP , Tyrosinase | |
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr... | |||
T10664 | Calcium 2-oxoglutarate | Others , Tyrosinase | |
Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM). | |||
T75714 | Decapeptide-12 | ||
Decapeptide-12, a competitive inhibitor of mushroom tyrosinase with an IC50 of 40 µM and a Kd of 61.1 μM for the C-terminal residue of tyrosinase, is a small oligopeptide that reduces melanin content in melanocytes by in... | |||
T2S0799 | Noroxyhydrastinine | Tyrosinase | |
Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, TRP-1, and TRP-2 in α-MSH-stimulated B16 ... | |||
T61780 | MtTMPK-IN-4 | ||
MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory... | |||
T76347 | Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 | ||
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect in rat models [1] [2]. | |||
T37832 | CAY10761 | CAY10761 | |
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) an... |