tl1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T34888	TL12-186	TL12 186,TL12186	CDK , Ligand for E3 Ligase
	TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.		CDK , Ligand for E3 Ligase
T13017	STL127705	Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK , Others
	STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM.		DNA-PK , Others
T37084	TL13-22	TL 13-22
	Negative control for TL 13-12 . Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC50 = 0.54 nM) Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med....
T13930	TL13-12		Others
	TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).		Others
T27560	HTL14242	HTL 14242,HTL-14242
	HTL14242 is a mGlu5 Negative Allosteric Modulator.
T34889	TL13-149	TL13149,TL13 149
	TL13-149 is an AC220-based FLT3 degrader.
T37083	TL13-110	TL 13-110
	Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM). Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase. J.Med.Chem. 6...
T13929	TL13-112		Others
	TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).		Others
T34890	TL13-27	TL13 27
	TL13-27 is a negative control for TL12-186.
T73443	STL1267
	STL1267, a potent REV-ERB agonist capable of crossing the blood-brain barrier, exhibits a K i value of 0.16 µM for REV-ERBα without demonstrating cytotoxicity. It effectively inhibits the gene expression of BMAL1.

Compounds

TL12-186

T34888

Synonym: TL12 186,TL12186

Target: CDK, Ligand for E3 Ligase

STL127705

T13017

Synonym: Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Target: DNA-PK, Others

Synonym: HTL 14242,HTL-14242

Target:

TL13-149

T34889

Synonym: TL13149,TL13 149

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04645	TL1A/TNFSF15 Protein, Human, Recombinant (hFc)	Human	HEK293
	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ...
TMPJ-00603	TL1A/TNFSF15 Protein, Mouse, Recombinant	Mouse	E. coli
	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor ...
TMPK-01012	TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or col...
TMPK-01013	TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or col...
TMPK-01011	TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293
	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or col...
TMPK-00143	TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)	Human	HEK293
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro an...
TMPY-04978	TL1A/TNFSF15 Protein, Human, Recombinant (rFc)	Human	HEK293
	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ...
TMPY-04979	TL1A/TNFSF15 Protein, Human, Recombinant (mFc)	Human	HEK293
	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ...
TMPY-05802	TL1A/TNFSF15 Protein, Human, Recombinant (His)	Human	HEK293
	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ...
TMPK-00489	TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus macaque	HEK293
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro an...
TMPY-01661	METTL1 Protein, Human, Recombinant (His)	Human	E. coli
	tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. M...
TMPY-01284	METTL11A Protein, Human, Recombinant (GST)	Human	E. coli
	Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPK-00685	CYTL1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Cytokine-like protein 1 (Cytl1), also named Protein C17 or C4orf4 is located on human chromosome 4p15-p16 and encodes a polypeptide of 126 amino acid residues that displays characteristics of a secretory protein. Cytl1 i...
TMPY-02556	FSTL1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	FSTL1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.9 kDa and the accession number is Q62356.
TMPY-01106	FSTL1 Protein, Human, Recombinant (His)	Human	HEK293
	Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a mu...
TMPY-00613	FSTL1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a mu...
TMPY-04084	ANGPTL1 Protein, Canine, Recombinant (hFc)	Canine	HEK293
	Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an im...
TMPJ-00191	FSTL1 Protein, Human, Recombinant	Human	E. coli
	Follistatin-Related Protein 1 (FSTL1) is a secreted protein that contains two EF-hand domains, one follistatin-like domain, one Kazal-like domain, and one VWFC domain. Its functional significance in physiological and pat...
TMPY-03067	TL1A/TNFSF15 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ...
TMPJ-01223	GALNTL1 Protein, Human, Recombinant (His)	Human	Human Cells
	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 1, also known as Polypeptide GalNAc transferase-like protein 1, Protein-UDP acetylgalactosaminyltransferase-like protein 1, UDP-GalNAc:polypeptide N-ace...
TMPY-04210	CSTL1 Protein, Human, Recombinant (hFc)	Human	HEK293
	CSTL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 41.6 kDa. Accession number: AAI17397.1
TMPY-00044	CYTL1 Protein, Human, Recombinant (mFc)	Human	HEK293
	Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known protein. Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first ...
TMPY-01285	METTL11A Protein, Human, Recombinant	Human	E. coli
	Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...