Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 1,080.00 |
Description | TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM). |
Targets&IC50 | Cereblon:2.4 μM |
In vitro | TL13-112 binds to cereblon(IC50 of 2.4 uM). in H3122 cell and Karpas 299, TL13-112 (0.01 μM-1 μM; 16 hours)?is selective for degradation of ALK(DC50s of 10 nM and 40 nM, respectively). ALK degradation acts at 4 hours of treatment in H3122 cells and at 8 hours of treatment in Karpas 299 cells. The maximum degradation achieves at 16 hours in both cell lines. .TL13-112 (0.01 μM-1 μM; 16 hours) inhibits PTK2, ALK, FER, RPS6KA1 and Aurora A expression as a dose-dependent manner in H3122, Karpas 299, and Kelly cells. |
Molecular Weight | 1002.57 |
Formula | C49H60ClN9O10S |
CAS No. | 2229037-19-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TL13-112 2229037-19-6 Others PROTAC PROTACs TL13 112 TL-13-112 TL13112 inhibitor inhibit