t-all — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16133	MRK-560		Gamma-secretase
	MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.		Gamma-secretase
T6603	Nelarabine	GW 506U78,Nelzarabine,506U78	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T72984	(Rac)-SHIN2		Others
	(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL).		Others
T3448	GJ103		Others
	GJ103 sodium salt is an active analog of the read-through compound GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and I...		Others
T36944	Ara-G		Nucleoside Antimetabolite/Analog
	Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate...		Nucleoside Antimetabolite/Analog
T39799	S2157	S2157
	S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound tri...
T79377	NWP-0476
	NWP-0476 is a modified BCL-2/BCL-xL inhibitor with enhanced specificity for BCL-xL, suitable for research on relapsed T-acute lymphoblastic leukemia (T-ALL) [1].
T39800	S2116
	S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing recipr...
T83930	SJ 11646
	SJ 11646, a potent lymphocyte-specific protein tyrosine kinase (LCK) Degrader (PROTAC) with a DC50 of 0.00838 pM, utilizes Dasatinib as the LCK ligand and incorporates a phenyl glutarimide-based cereblon binder. Demonstr...
T60966	UCPH-102
	UCPH-102 can be used in Alzheimer’s disease, amyotrophic lateral sclerosis, chronic pain and obsessive compulsive disorder studies with good blood-brain permeability. UCPH-102 is a highly selective inhibitor of EAAT1 wit...
T36693	FD-211
	FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respective...
T37553	(-)-Mycousnine
	(-)-Mycousnine is a microbial metabolite and derivative of usnic acid originally isolated fromM. nawaethat has antibacterial and antifungal activities.1,2It is active against the Gram-positive bacteriaB. subtilis,K. rhiz...
T37887	1-Heptadecanoyl-rac-glycerol
	1-Heptadecanoyl-rac-glycerol is a monoacylglycerol that contains heptadecanoic acid at the sn-1 position. It is active against the bacteria E. aerogens, E. cloacae, P. mirabilis, and S. faecalis (MIC = 78 μg/ml for all)....
T37536	Carbazomycin A
	Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well a...
T37330	Pyridindolol
	Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selecti...
T38381	CAY17c
	CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and cla...
T35810	C24 dihydro Ceramide (d18:0/24:0)	Cer(d18:0/24:0)
	C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c...
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and ...
T35890	Pentosidine
	Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditi...