sphk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9992	SphK1&2-IN-1		S1P Receptor
	SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.		S1P Receptor
T61965	SphK1-IN-1
	SphK1-IN-1 is an inhibitor of SphK1 with anti-tumor activity. SphK1-IN-1 inhibits the ATPase of SphK1, IC50=2.48 μM. SphK1-IN-1 has the value of cancer research.
T63835	SphK1-IN-2
	SphK1-IN-2 is a potent and selective SphK1 inhibitor that acts on both SphK1 (IC50: 19.81 nM) and SphK2 (IC50>10 nM). sphK1-IN-2 induces cell cycle arrest and apoptosis, exhibits anti-proliferative effects, and can be us...
T6085	PF-543	Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T8840	PF-543 hydrochloride	PF-543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T63047	SLP9101555		S1P Receptor , LPL Receptor
	SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace...		S1P Receptor , LPL Receptor
T16128	MP-A08		S1P Receptor
	MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).		S1P Receptor
T4658	MHP	Methyl caprooyl tyrosinate	S1P Receptor
	MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.		S1P Receptor
T27710	K6PC-5	K6PC5,K6PC 5	S1P Receptor
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ...		S1P Receptor
T0640	Benzyl butyl phthalate	BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate	Others , Aryl Hydrocarbon Receptor
	Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC.		Others , Aryl Hydrocarbon Receptor
T12436	PF-543 Citrate	Sphingosine Kinase 1 Inhibitor II Citrate	S1P Receptor
	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).		S1P Receptor
T12927	SK1-IN-1		S1P Receptor
	SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).		S1P Receptor
T28803	SLC5111312 HCl	SLC5111312 hydrochloride,SLC 5111312,SLC-5111312,SLC5111312
	SLC5111312 is an inhibitor of SphK1 and SphK2.
T34658	SLP7111228	SLP-7111228,SLP 7111228
	SLP7111228 is an effective and selective SphK1 inhibitor (Ki = 48 nM).
T28801	SLC4011540	SLC-4011540,SLC 4011540
	SLC4011540 is a potent and selective SphK1/2 dual inhibitor with Ki value of 120 nM and 90 nM respectively.
T83883	Biotin Sphingosine	Biotinyl Sphingosine
	Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates.
T63132	Amgen-23
	Amgen-23 (compound 23) is a potent inhibitor of sphingosine kinase (SPHK), acting on SPHK1 (IC50: 20 μM) and SPHK2 (IC50: 1.6 μM). amgen-23 can be used in anticancer studies.
T11739	K145		Others
	K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 ...		Others
T70614	SLR080811 HCl
	SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h...