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SLC4011540

Catalog No. T28801 CAS T28801

Synonyms: SLC-4011540, SLC 4011540

SLC4011540 is a potent and selective SphK1/2 dual inhibitor with Ki value of 120 nM and 90 nM respectively.

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SLC4011540, CAS T28801

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

SLC4011540 is a potent and selective SphK1/2 dual inhibitor with Ki value of 120 nM and 90 nM respectively.

Synonyms	SLC-4011540, SLC 4011540
Molecular Weight	550
Formula	C24H23ClF3N7OS
CAS No.	T28801

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Childress ES, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and In Vivo Activity. J Med Chem. 2017 Apr 13. doi: 10.1021/acs.jmedchem.7b00233. [Epub ahead of print] PubMed PMID: 28406646.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SLC4011540 T28801 SLC-4011540 SLC 4011540 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.