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MP-A08

Catalog No. T16128 CAS 219832-49-2

MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).

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MP-A08, CAS 219832-49-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 173.00
50 mg	In stock	$ 322.00
100 mg	In stock	$ 572.00
500 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 98.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).
In vitro	MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. MP-A08 blocks pro-proliferative signaling pathways causes mitochondrial-associated apoptosis in an SK-dependent manner. It also reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis [2]
In vivo	MP-A08 inhibits the growth of human lung tumour xenografts in mice.

Molecular Weight	519.64
Formula	C27H25N3O4S2
CAS No.	219832-49-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: insoluble

DMSO: 50 mg/mL (96.22 mM)

References and Literature

1. Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar 30, 6(9):7065-83. 2. Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation, 2016 Apr, 23(3):248-65.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Highly Selective Inhibitor Library Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Cancer Compound Library

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CS 2100 S1p receptor agonist 1 CYM5442 PF-543 Citrate PF429242 dihydrochloride GLPG2938 Ozanimod SKI II

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MP-A08 219832-49-2 GPCR/G Protein S1P Receptor MPA08 SphK Sphingosine kinase MP-A-08 inhibit Inhibitor MP A08 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.