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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T20419 | Raloxifene | Pharoxifene,Raloxifenum,Keoxifene,LY-139481 | Estrogen Receptor/ERR , Others |
Raloxifene (LY-139481) is a selective oestrogen receptor modulator. It has effects on bone and breast cancer and cardiovascular disease risk. | |||
T1549 | Raloxifene hydrochloride | LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl | Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy |
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol... | |||
T40938 | Raloxifene dimethyl ester hydrochloride | Diacyl-raloxifene hydrochloride,Raloxifenediacylanalog | |
Raloxifene dimethyl ester hydrochloride is an analog of Raloxifene. | |||
T39298 | Raloxifene 4-Monomethyl Ether | ||
Raloxifene 4-Monomethyl Ether (Compound 37) is a derivative of Raloxifene which acts as an inhibitor of estrogen receptor α. It effectively suppresses the activity of MCF-7 cells, exhibiting an IC50 value of 1 μM and a p... | |||
T39203 | Raloxifene 6-Monomethyl Ether | ||
Compound 7, or Raloxifene 6-Monomethyl Ether, is a derivative of Raloxifene that effectively inhibits estrogen receptor α. It also displays the inhibitory effects on MCF-7 cells, with an IC50 of 250 nM and a pIC50 of 6.6... | |||
T19545 | Raloxifene N-Oxide | Others | |
Raloxifene N-Oxide is a Raloxifene oxidative degradation product. | |||
T12686 | Raloxifene 4'-glucuronide | Others | |
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. | |||
T12688 | Raloxifene 6-glucuronide | Others | |
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. | |||
T19544 | Raloxifene Bismethyl Ether | Others | |
Raloxifene Bismethyl Ether is a Raloxifene metabolite and an estrogen receptor inactive compound on which both hydroxyl groups are absent. | |||
T19543 | Raloxifene Bismethyl Ether hydrochloride | Others | |
Raloxifene Bismethyl Ether hydrochloride is a Raloxifene metabolite and an estrogen receptor inactive compound on which both hydroxyl groups are absent. | |||
T10187 | 6-Raloxifene-β-D-glucopyranoside | Others | |
6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone l... | |||
T10155 | 4'-Raloxifene-β-D-glucopyranoside | Others | |
4'-Raloxifene-β-D-glucopyranoside is a metabolite of Raloxifene. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. | |||
T12687 | Raloxifene 6,4'-Bis-β-D-glucuronide | Others | |
Raloxifene 6,4'-Bis-β-D-glucuronide is a Raloxifene metabolite. Raloxifene is a selective antagonist of estrogen receptor for the prevention of osteoporosis. | |||
T19141 | 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene | Others | |
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. | |||
T10189 | 7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene | Others | |
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist (IC50: 3.1 μM). | |||
T19425 | Methyl Raloxifene 4'-(2,3,4-Tri-O-acetyl-β-D-glycopyranuronate) | Others | |
Methyl Raloxifene 4'-(2,3,4-Tri-O-acetyl-β-D-glycopyranuronate) is a derivative compound of Raloxifene 4'-glucuronide, designed to resemble its structure and function. | |||
T9001 | Desketoraloxifene | Phospholipase | |
Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2). | |||
T11915 | LY88074 | Estrogen/progestogen Receptor | |
LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation. | |||
TN2211 | Silybin B | Silibinin B | Apoptosis , Beta Amyloid , Bcr-Abl |
Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-dipheny... | |||
T15800 | LY117018 | PI3K | |
LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator. |