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Silybin B

Catalog No. TN2211   CAS 142797-34-0
Synonyms: Silibinin B

Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis.

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Silybin B Chemical Structure
Silybin B, CAS 142797-34-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 122.00
5 mg In stock $ 328.00
10 mg In stock $ 493.00
25 mg In stock $ 788.00
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1 mL * 10 mM (in DMSO) In stock $ 349.00
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Purity: 99.66%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis.
In vitro The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.[1]
In vivo Silybin B markedly improved the behavioral abnormalities in cisplatin-treated mice and reduced LPO levels while increasing SOD, GSH, and T-AOC in mice brain tissue. Nissl staining and Tunel assay showed that silybin B alleviated cisplatin-induced hippocampal damage.[2]
Synonyms Silibinin B
Molecular Weight 482.44
Formula C25H22O10
CAS No. 142797-34-0

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (466.4 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Zhang J, et al. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Nat Prod Commun. 2011;6(11):1653-1656. 2. Wang XL, et al. Silybin B exerts protective effect on cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. J Ethnopharmacol. 2022;288:114938.

Related compound libraries

This product is contained In the following compound libraries:
Rare Natural Product Library Natural Product Library for HTS Neuronal Signaling Compound Library Flavonoid Natural Product Library

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Keywords

Silybin B 142797-34-0 Angiogenesis Apoptosis Cytoskeletal Signaling Neuroscience Tyrosine Kinase/Adaptors Bcr-Abl Beta Amyloid Silibinin B inhibitor inhibit

 

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