pde3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8462	Enoximone		PDE
	Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.		PDE
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE
T1708	Pimobendan	Acardi,Pimobendane,UD-CG 115 BS,UD-CG115	PDE
	Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).		PDE
T5106	BRL-50481		PDE
	BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.		PDE
T1713	IBMX	3-Isobutyl-1-methylxanthine,1-Methyl-3-Isobutylxanthine,Methylisobutylxanthine,Isobutylmethylxanthine	PDE
	IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM). IBMX enhances the intracellular cAMP level.		PDE
T27632	Isomazole		PDE
	Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.		PDE
T23638	Adibendan	Adibendanum	PDE
	Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.		PDE
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T21457	Carbazeran	UK-31557,UK31,557,UK-31,557,UK31557,UK 31557,UK 31,557	PDE
	Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects in vivo(EC50 = 100 μM).		PDE
T71691	Pumafentrine	BY 343	PDE
	Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.		PDE
TN1266	3-O-Methylquercetin		IL Receptor , cAMP , PDE
	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...		IL Receptor , cAMP , PDE
T12267	NSP-805		PDE
	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.		PDE
T23411L	T-0156	T 0156	PDE , Parasite
	T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.		PDE , Parasite
T1096	Milrinone	Win 47203	PDE
	Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.		PDE
T17284	Zardaverine	BY 290,B 84290	PDE
	Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and...		PDE
T3465L	Vesnarinone HCl	Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel , Calcium Channel , PDE
	Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new...		Potassium Channel , Calcium Channel , PDE
T7642	Cilostamide	OPC3689	PDE
	Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)		PDE
T8405	Vardenafil hydrochloride		PDE
	Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes		PDE
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE
T12913	Siguazodan	SKF 94836	PDE
	Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM. Siguazodan inhibited phenylephrine induced 5-HT release with an IC50 value of 4.2 μM。 S...		PDE