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NSP-805

Catalog No. T12267 CAS 125068-54-4

NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.

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NSP-805, CAS 125068-54-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
2 mg	In stock	$ 118.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 337.00
25 mg	In stock	$ 572.00
50 mg	In stock	$ 818.00
100 mg	In stock	$ 1,130.00
500 mg	In stock	$ 2,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 217.00

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Purity: 99.10%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
In vitro	In isolated guinea pig left atria, the positive inotropic EC50 values (microM) in order of potency were about 0.18 (NSP-805), 0.39 (indolidan), 1.1 (MCI-154), 1.7 (NSP-804, milrinone), 2.0 (denopamine), 4.0 (papaverine), 4.4 3-isobutyl-1-methylxanthine, IBMX, 6.5 (imazodan), and 27 (amrinone)[1].
In vivo	In anesthetized dogs, intravenous (i.v.) injection of NSP-804 and NSP-805 produced dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR).?The ED50 values (micrograms/kg) for LVdP/dtmax of NSP-804, NSP-805, denopamine, milrinone, MCI-154, and indolidan were 15, 12, 22, 23, 15, and 7.3, respectively.?When the drugs were administered intraduodenally to anesthetized dogs, the ED50 values (micrograms/kg) for LVdP/dtmax of NSP-804, NSP-805, milrinone and indolidan were approximately 30, 10, 200, and 25 respectively.?In the propranolol-induced heart failure model, NSP-804 and NSP-805 completely improved the hemodynamic state of heart failure to normal levels.?The in vitro positive inotropic effects of NSP-804 and NSP-805 were accompanied by increases in tissue cyclic AMP and abolished by carbachol.?NSP-805 was the most potent and selective inhibitor of guinea pig cardiac phosphodiesterase (PDE) III among the agents examined, and NSP-804 was a potent and selective inhibitor of PDE III similar to indolidan[1].

Molecular Weight	297.35
Formula	C17H19N3O2
CAS No.	125068-54-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/ml (67.26 mM)

References and Literature

1. Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95. 2. Uchida H, et al. [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai Zasshi. 2002 Oct;106(10):615-20.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library ReFRAME Related Library Bioactive Compound Library NO PAINS Compound Library Cuproptosis Compound Library

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Keywords

NSP-805 125068-54-4 Metabolism PDE Inhibitor NSP 805 inhibit Phosphodiesterase (PDE) NSP805 inhibitor

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