10
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6253 | Talazoparib | LT-673,BMN-673 | PARP |
Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). | |||
T22094 | JGB1741 | ILS-JGB-1741 | Sirtuin |
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-m... | |||
T3S1471 | Cucurbitacin IIA | Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA | Apoptosis , Survivin |
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ... | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T2S2362 | Dehydrocorydaline nitrate | BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy | |
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... | |||
T28293 | Pamiparib maleate | BGB290,BGB 290,BGB-29 maleat 0 | |
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the acc... | |||
T70115 | Pamiparib hydrate | ||
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of sin... | |||
T26229 | ST7710AA1 | ST-7710-AA1,ST 7710 AA1 | |
ST7710AA1 is a PARP-1 inhibitor that acts by showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp. | |||
TN1139 | Dehydrocavidine | Dehydrocorydaline | BCL , PARP |
Dehydrocavidine (Dehydrocorydaline) has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP. | |||
T69200 | CGP74514A | ||
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t... |