p2y6 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4706	Uridine-5'-diphosphate disodium salt	UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd	DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor
	Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction...		DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor
T6172	MRS 2578		Apoptosis , P2Y Receptor
	MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.		Apoptosis , P2Y Receptor
T63534	PPTN hydrochloride		P2Y Receptor
	PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12 or P2Y13 receptors, exhib...		P2Y Receptor
T12530	PPTN		P2Y Receptor
	PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.		P2Y Receptor
T8946	Indophagolin		P2X Receptor , 5-HT Receptor , Autophagy
	Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.		P2X Receptor , 5-HT Receptor , Autophagy
T23192	PSB 0474		Others
	P2Y6 receptor agonist		Others
T78583	Uridine 5'-diphosphate		P2Y Receptor
	Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].		P2Y Receptor
T16139	MRS2698		Epigenetic Reader Domain
	MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors.		Epigenetic Reader Domain
T16672	PSB-1114 tetrasodium
	PSB-1114 tetrasodium shows >50-fold selectivity versus the P2Y4 (EC50: 9.3 μM) and P2Y6 (EC50: 7.0 μM) receptors. PSB-1114 tetrasodium is an effective, enzymatically stable, and subtype-selective P2Y2 receptor agonist (E...
T28102	MRS2567	MRS-2567,MRS 2567
	MRS2567 is a potent P2Y6 nucleotide receptors antagonists.
T22525	5-OMe-UDP trisodium salt		Others
	Potent P2Y6 agonist		Others
T37129	MRS 2905
	Potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6. Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and...
TP2271	MRS 2957 triethylammonium salt		Others
	MRS 2957 triethylammonium salt is a P2Y6 agonist.		Others
T23025	MRS 2693 trisodium salt		Others
	MRS 2693 trisodium salt is a P2Y6 agonist.		Others
T78080	PSB-1114 triethylamine		P2Y Receptor
	PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors [1].		P2Y Receptor
T83803	UDP-β-S sodium	Uridine-5' O-(2-thiodiphosphate)
	UDP-β-S, serving as a specific agonist for the purinergic P2Y6 receptor, effectively promotes inositol phosphate accumulation in 1321N1 cells containing P2Y6 receptors, with an EC50 value of 28 nM. This selectivity is ev...
T28099	MRS2179	MRS 2179,MRS-2179
	MRS2179 is a competitive P2Y1 receptor antagonist (Kb = 100 nM) with no appreciable activity at P2Y2, P2Y4, or P2Y6 at concentrations up to 30 µM, or at P2Y12 and P2Y13. It inhibits ADP-induced platelet shape change and ...
T13264	Uridine 5'-diphosphate sodium salt		Others
	Uridine 5'-diphosphate sodium salt is a selective native agonist of the P2Y6 receptor (EC50: 300 nM; pEC50: 6.52), and also is a potent antagonist of P2Y14 (pEC50: 7.28).		Others
T83839	Uridine 5'-methylenediphosphate sodium	α,β-methylene UDP,UMP-CP
	Uridine 5’-methylenediphosphate (UMP-CP), a hydrolytically stable derivative of UDP and agonist of the purinergic P2Y14 receptor, exhibits selective inhibition of cAMP production in cells expressing human P2Y14 compared ...
T64078	MRS2179 tetrasodium hydrate
	MRS2179 tetrasodium hydrate, a competitive antagonist of the P2Y1 receptor, acts on the turkey P2Y1 receptor (Kb: 102 nM, pA2: 6.99) and exhibits an inhibitory effect on platelet aggregation. IC50: 1.15 μM), P2X3 (IC50: ...