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Uridine 5'-diphosphate sodium salt

Catalog No. T13264 CAS 21931-53-3

Uridine 5'-diphosphate sodium salt is a selective native agonist of the P2Y6 receptor (EC50: 300 nM; pEC50: 6.52), and also is a potent antagonist of P2Y14 (pEC50: 7.28).

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Uridine 5'-diphosphate sodium salt Chemical Structure

Uridine 5'-diphosphate sodium salt, CAS 21931-53-3

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Description

Uridine 5'-diphosphate sodium salt is a selective native agonist of the P2Y6 receptor (EC50: 300 nM; pEC50: 6.52), and also is a potent antagonist of P2Y14 (pEC50: 7.28).

In vitro

microglial CCL2 and CCL3 mRNA expression significantly induced by Uridine 5'-diphosphate sodium salt (100 μM; for 15 min)[2]. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2]. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2]. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2]. Activation of NFATc1 and NFATc2 in microglia induced by Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) [2].

Molecular Weight	470.106
Formula	C9H11N2Na3O12P2
CAS No.	21931-53-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. 2. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.

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