os1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T73164	SOS1-IN-15		Raf
	SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.		Raf
T60029	SOS1-IN-11		Raf
	SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).		Raf
T67699L	ALK/ROS1 inhibitor 2e HCL	(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)	Apoptosis
	ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.		Apoptosis
T37696	NOS1-IN-1	nNOS Inhibitor I	NOS
	NOS1-IN-1（nNOS Inhibitor I） is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorde...		NOS
T62478	SOS1-IN-9
	SOS1-IN-9 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 116.5 nM).
T62923	SOS1-IN-7
	SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).
T63887	SOS1-IN-14
	SOS1-IN-14 is a selective, potent, orally active SOS1 inhibitor (IC50: 3.9 nM). sOS1-IN-14 is absorbed in the intestine using a P-glycoprotein-mediated efflux mechanism. sOS1-IN-14 can be used in the study of KRAS mutate...
T62371	SOS1-IN-12
	SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).
T63201	SOS1 activator 1
	SOS1 activator 1 is an activator of SOS1-mediated nucleotide exchange (Kd: 44 nM).SOS1 is a guanine nucleotide exchange factor that binds to Ras proteins and catalyzes the exchange of GDP for GTP on RAS, resulting in the...
T62712	SOS1-IN-10
	SOS1-IN-10 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 13 nM).
T79183	SOS1-IN-16		Ras
	SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of 8.9μM when testosterone is employed as a substrate. This co...		Ras
T79162	SOS1/KRAS-IN-1		Ras
	SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].		Ras
T61478	ROS1-IN-1
	ROS1-IN-1 (Compound 31) is a highly effective and specific inhibitor of the ROS1 kinase, displaying a remarkable inhibitory concentration (IC 50) of 0.097 μM [1].
TP2116	SAH-SOS1A
	KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a conc...
T79098	PROTAC SOS1 degrader-4		PROTACs
	PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].		PROTACs
T63118	SOS1-IN-8
	SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).
T10286	ALK/ROS1-IN-1		Others
	ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).		Others
T61963	SOS1-IN-3
	SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.
T32414	KOS1326	KOS-1326,KOS 1326
	KOS1326 is a bioactive chemical.
T63083	SOS1-IN-4
	SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.
T75020	PROTAC SOS1 degrader-3
	PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1].
T76059	SAH-SOS1A TFA
	SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA di...
T63781	SOS1-IN-5
	SOS1-IN-5 is a pyrimidine bicyclic derivative and a potent inhibitor of SOS1. SOS1-IN-5 interferes with the RAS-SOS1 interaction, thereby blocking KRAS activation and exhibiting broad-spectrum inhibition of KRAS activity...
T63044	SOS1-IN-6
	SOS1-IN-6 (compound 33-P1) is a potent inhibitor of SOS1, acting on SOS1-G12D (IC50: 14.9 nM) and SOS1-G12V (IC50: 73.3 nM).
T74356	PROTAC SOS1 degrader-2
	PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
T62003	SOS1-IN-13
	SOS1-IN-13 is a potent inhibitor of son of sevenless homolog 1 (SOS1). SOS1-IN-13 shows IC 50 s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 has research value in anticancer.
T74439	PROTAC SOS1 degrader-1
	PROTAC SOS1 degrader-1, a potent compound, demonstrates an effective degradation of PROTAC SOS1 with a DC50 value of 98.4 nM. It exhibits antiproliferative activity against cancer cells harboring diverse KRAS mutations a...

Compounds

SOS1-IN-15

T73164

ALK/ROS1 inhibitor 2e HCL

T67699L

Synonym: (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)

Target: Apoptosis

NOS1-IN-1

T37696

Synonym: nNOS Inhibitor I

PROTAC SOS1 degrader-4

Synonym: KOS-1326,KOS 1326

PROTAC SOS1 degrader-3

PROTAC SOS1 degrader-2

PROTAC SOS1 degrader-1

T74439

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03847	FRZB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In t...
TMPY-03848	Protein S/PROS1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Protein S/PROS1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.1 kDa and the accession number is P07225.
TMPY-06708	Protein S/PROS1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Protein S/PROS1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.75 kDa and the accession number is Q08761.
TMPY-06315	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.18 kDa and the accession number is A0A7N9CCZ7.
TMPU-00002	SOS1-Cat Protein, Human, Recombinant (His)	Human	E. coli
	Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM...