nurr1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T77549	Nurr1 agonist 2		Others
	Nurr1 agonist 2 is a Nurr1 agonist with an EC50 value of 0.07 μM. Nurr1 agonist 2 increases the mRNA expression of the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2). Nurr1...		Others
T78088	Nurr1 agonist 4		Others
	Nurr1 agonist 4 (compound 8) serves as a potent Nurr1 agonist, exhibiting an EC50 value of 2.1 μM [1].		Others
T81634	Nurr1 agonist 6
	Compound 13, a Nurr1 agonist, exhibits a dissociation constant (Kd) of 1.5 μM and an effective concentration for 50% response (EC50) of 3 μM [1].
T81632	Nurr1 agonist 8
	Compound 111 (Nurr1 agonist 8) is a Nurr1 agonist exhibiting an EC50 value of 0.09 μM [1].
T81633	Nurr1 agonist 7
	Nurr1 agonist 7 (compound 110) is an agonist targeting the Nurr1 receptor and exhibits an EC50 of 0.12 μM [1].
T60443	Nurr1 agonist 1
	Nurr1 agonist 1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1 which is an appealing target to treat neurodegenerative diseases.
T81635	Nurr1 agonist 5
	Compound 5o, a Nurr1 agonist, exhibits neuroprotective properties as a transcription factor Nurr1 agonist, possessing a dissociation constant (Kd) of 0.5 μM and a half-maximal effective concentration (EC50) of 3 μM [1].
T83894	4A7C-301-Nurr1 Agonist	4A7C-301-Nuclear Receptor-Related 1
	The compound 4A7C-301-Nurr1 agonist is a specific agonist for the nuclear receptor-related 1 (Nurr1). By binding to the Nurr1 ligand-binding domain with an IC50 value of 48.22 nM, it enhances the transcriptional activity...
T78049	Nurr1 inverse agonist-1		Others
	Nurr1 Inverse Agonist-1 is an inverse agonist for the neuroprotective transcription factor Nurr1, serving as a research tool.		Others
T8381	Amodiaquine		Others , Histone Methyltransferase , Parasite
	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.		Others , Histone Methyltransferase , Parasite
T27620	IP7e	IP 7e,IP-7e,isoxazolo-pyridinone 7e	Others
	IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM.		Others
T0381	Amodiaquine dihydrochloride dihydrate	Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase , Parasite , Histamine Receptor
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.		Histone Methyltransferase , Parasite , Histamine Receptor
T3106	C-DIM12		Apoptosis , Others
	C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure ...		Apoptosis , Others
T35159	XCT0135908	XCT 0135908,XCT-0135908
	XCT0135908 is a selectivity agonist of RXR -Nurr1 over a broad range of other RXR dimerization partners but with a rather low potency.
T70237	HX-600
	HX-600 is a synthetic agonist for the RXR-Nurr1 heterodimer complex. HX-600 prevents ischemia-induced neuronal damage.
T22242	Amodiaquine hydrochloride
	Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, serves as an antimalarial agent and exhibits potent oral activity as a histamine N-methyltransferase inhibitor, displaying...
T69921	BRF110
	BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and str...
T83328	4A7C-301
	4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor and olfactory functions in male mouse models with AAV2-mediated α-s...