nkg2d — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T81669	NKG2D-IN-2
	NKG2D-IN-2 (compound 47) is an inhibitor of the natural killer group 2D receptor (NKG2D), demonstrating half-maximal inhibitory concentrations (IC50s) of 0.1 µM for NKG2D/MICA and 0.2 µM for ULBP6 in time-resolved fluore...
T81670	NKG2D-IN-1
	NKG2D-IN-1, also known as compound 21, is an inhibitor of the natural killer group 2D receptor (NKG2D) exhibiting inhibitory concentration 50 (IC50) values of 0.3 µM in NKG2D/MICA TR-FRET assays and 0.7 µM in ULBP6 TR-FR...
T77404	Tesnatilimab	IPH-23XX,JNJ-64304500,JNJ 4500	Others
	Tesnatilimab is a potent humanized IgG4 monoclonal antibody that binds to the immune-activating receptor NKG2D. Tesnatilimab has potential immunomodulatory and anti-inflammatory activity and can be used to study active u...

Recombinant Proteins

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Expression System：

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Cat No.	Product Name	Species	Expression System
TMPY-05414	NKG2D/CD314 Protein, Mouse, Recombinant (hFc)	Mouse	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-00467	NKG2D/CD314 Protein, Human, Recombinant (hFc)	Human	CHO
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-03376	NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His)	Rhesus	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-03256	NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)	Human	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPK-00107	NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled	Human	HEK293
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate l...
TMPK-00106	NKG2D/CD314 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate l...
TMPK-00105	NKG2D/CD314 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate l...
TMPK-00108	NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag)	Human	HEK293
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate l...
TMPY-06827	NKG2D/CD314 Protein, Human, Recombinant (mFc)	Human	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPJ-00122	NKG2D/CD314 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As...
TMPJ-00097	NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	Human Cells
	NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As...
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, E...
TMPK-00137	ULBP-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	ULBP2 expression was however linked to expression of mature CD57() NK cells. In particular, expression of ULBP2 was strongest on those NK cells that had evidence of recent activation and proliferation. We suggest that UL...
TMPJ-00131	NKG2DL Protein, Human, Recombinant (hFc)	Human	Human Cells
	NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC ...
TMPK-00135	ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natu...
TMPK-00134	ULBP-1 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natu...
TMPY-05592	ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated	Human	HEK293
	NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e...
TMPY-02333	ULBP-2 Protein, Human, Recombinant (His)	Human	HEK293
	NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e...
TMPY-01066	MICB Protein, Human, Recombinant (His)	Human	HEK293
	MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related prote...
TMPY-05476	MICA Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ...
TMPY-02053	MICA Protein, Human, Recombinant (His), MICA*018	Human	HEK293
	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ...
TMPY-00586	CLEC-2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, ...
TMPY-05074	NKG2A/CD159a Protein, Human, Recombinant (aa 94-233, His)	Human	HEK293
	NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this family are characteriz...
TMPY-03686	NKG2A/CD159a Protein, Cynomolgus/Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293
	NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this family are characteriz...
TMPY-02334	ULBP-2 Protein, Human, Recombinant (hFc)	Human	HEK293
	NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e...
TMPK-00245	MICB Protein, Human, Recombinant (His & Avi)	Human	HEK293
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antige...
TMPK-00247	MICB Protein, Human, Recombinant (hFc)	Human	HEK293
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antige...
TMPK-00246	MICB Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antige...
TMPY-05830	MICA Protein, Human, Recombinant (hFc), MICA*018	Human	HEK293
	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ...
TMPY-05591	ULBP-1 Protein, Human,Recombinant(aa 1-216, His&AVI),Biotinylated	Human	HEK293
	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially func...
TMPY-05469	MICA Protein, Human, Recombinant (His), MICA*00801	Human	HEK293
	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ...
TMPY-00885	MICB Protein, Human, Recombinant (His & hFc)	Human	HEK293
	MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related prote...
TMPY-01405	ULBP-1 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially func...
TMPY-01156	ULBP-1 Protein, Human, Recombinant (His)	Human	HEK293
	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially func...
TMPY-00575	ULBP-6 Protein, Human, Recombinant (His)	Human	HEK293
	ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in...
TMPK-00219	MICA Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	TMICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly...
TMPY-00190	ULBP-6 Protein, Human, Recombinant (hFc)	Human	HEK293
	ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in...
TMPK-00220	MICA Protein, Human, Recombinant (hFc)	Human	HEK293
	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly ...
TMPK-00218	MICA Protein, Human, Recombinant (His & Avi)	Human	HEK293
	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly ...
TMPK-00221	MICA alpha 3 Protein, Human, Recombinant (mFc)	Human	HEK293
	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly ...
TMPY-03977	DAP10 Protein, Human, Recombinant (mFc)	Human	HEK293
	HCST (Hematopoietic Cell Signal Transducer, also known as DAP1) is a Protein Coding gene. HCST belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. Th...
TMPJ-01212	ULBP-1 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2...
TMPY-02357	CLEC-2 Protein, Human, Recombinant (His)	Human	HEK293
	CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, ...
TMPY-02894	NKG2A/CD159a Protein, Human, Recombinant (aa 100-233, His)	Human	HEK293
	NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this family are characteriz...
TMPY-06199	NKG2A/CD159a Protein, Human, Recombinant (hFc)	Human	HEK293
	NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this family are characteriz...
TMPY-05397	NKG2A/CD159a Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this family are characteriz...
TMPY-03778	NKG2A/CD159a Protein, Mouse, Recombinant (His)	Mouse	HEK293
	NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this family are characteriz...