mc4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T69823	MC4
	MC4 is a first-in-class inhibitor of ribosomal RNA synthesis with antimicrobial activity against Staphylococcus aureus.
T83656	DLIN-MC4-DMA		Others
	DLIN-MC4-DMA is a lipid membrane and is a potential nucleic acid carrier.		Others
T78156	MC4033		Apoptosis
	MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1]. Additionally, treatment with MC4033 at concentrations of 25, 50, 100, and 200 µM f...		Apoptosis
T63747	MC4355
	MC4355 is a dual inhibitor of EZH2 and histone deacetylase (HDAC).
T79086	MC4171		Histone Acetyltransferase
	MC4171 (compound 34), a selective KAT8 inhibitor (IC50=8.1 µM), demonstrates moderate antiproliferative activity at micromolar concentrations in various cancer cell lines, such as NSCLC and AML. This property highlights ...		Histone Acetyltransferase
T73484	MC4343
	MC4343, a potent dual inhibitor targeting both EZH2 and histone deacetylase, presents promising potential for cancer research applications.
TP1898	HS024	HS 024	Melanocortin Receptor
	HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-...		Melanocortin Receptor
T69526	PF-07258669		Melanocortin Receptor
	PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.		Melanocortin Receptor
TP1953L	PG 931 acetate	PG 931 acetate (667430-81-1 Free base)	Melanin-concentrating Hormone Receptor (MCHR)
	PG 931 acetate is a potent agonist of melanocortin 4 (MC4) receptors.		Melanin-concentrating Hormone Receptor (MCHR)
TP1889	MCL0020	MCL 0020	Melanocortin Receptor
	MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e...		Melanocortin Receptor
TP2015L	HS 014 acetate(207678-81-7 free base)		Melanocortin Receptor
	HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and no...		Melanocortin Receptor
TP1004L	Beta-MSH (1-22) (human) acetate	Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)	Melanocortin Receptor
	Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) , is an endogenous melanocortin-4 receptor (MC4-R) agonist.		Melanocortin Receptor
TP1893L1	[D-Trp8]-γ-MSH acetate(321351-81-9 free base)		Melanocortin Receptor
	[D-Trp8]-γ-MSH acetate(321351-81-9 free base) is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively) and displays anti-inflammatory ef...		Melanocortin Receptor
T22989	ML 00253764 hydrochloride		Others
	melanocortin MC4 receptor antagonist		Others
TP1953	PG-931	PG 931
	Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory ...
T68522	PF-446687
	PF-446687 is a highly selective MC4 receptor (MC4R) agonist.
T75852	HS024 TFA
	HS024, a selective MC4 receptor antagonist, exhibits affinity with Ki values of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1 receptors, respectively. This compound has been shown to increase food intake [1].
TP2011	JKC363	JKC 363
	Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 0.5 and 44.9 nM at MC4 and MC3 respectively) that antagonizes the effects of α-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, atten...
T27986	MCL0129	MCL-0129,MCL 0129
	MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T75853	HS014 TFA
	HS014 TFA, a potent and selective antagonist of the melanocortin-4 (MC4) receptor, exhibits K i values of 3.16, 108, 54.4, and 694 nM for the human MC4, MC1, MC3, and MC5 receptors, respectively. It effectively increases...