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HS 014 acetate(207678-81-7 free base)

Catalog No. TP2015L CAS TP2015L

HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.

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HS 014 acetate(207678-81-7 free base), CAS TP2015L

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	1623.83
Formula	C73H98N20O19S2
CAS No.	TP2015L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID: 2. Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID: 3. Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 54 509 PMID:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HS 014 acetate(207678-81-7 free base) TP2015L GPCR/G Protein Neuroscience Melanocortin Receptor HS 014 acetate(207678 81 7 free base) HS 014 acetate(207678817 free base) Inhibitor inhibitor inhibit

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