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[D-Trp8]-γ-MSH acetate(321351-81-9 free base)

Catalog No. TP1893L1 CAS TP1893L1

Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.

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[D-Trp8]-γ-MSH acetate(321351-81-9 free base), CAS TP1893L1

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Purity: 98%

Biological Description

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Description	Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
Targets&IC50	melanocortin-4 receptor (MC4R):600 nM, melanocortin 3 (MC3):6.7 Nm, melanocortin-5 receptor (MC5R):340 Nm

Molecular Weight	1630.82
Formula	C76H103N21O18S
CAS No.	TP1893L1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: Insoluble

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998 PMID: 2. Getting et al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850 PMID: 3. Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835 PMID:

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Keywords

[D-Trp8]-γ-MSH acetate(321351-81-9 free base) TP1893L1 GPCR/G Protein Neuroscience Melanocortin Receptor [D Trp8] γ MSH acetate(321351 81 9 free base) [DTrp8]γMSH acetate(321351819 free base) [D-Trp-8]-γ-MSH acetate(321351-81-9 free base) Inhibitor inhibitor inhibit

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