lrrk2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11878	LRRK2 inhibitor 1		LRRK2 , CDK
	LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.		LRRK2 , CDK
T2246	LRRK2-IN-1		Apoptosis , LRRK2 , CDK
	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.		Apoptosis , LRRK2 , CDK
T63620	LRRK2-IN-3
	LRRK2-IN-3 is a potent, selective, orally active LRRK2 inhibitor that crosses the blood-brain barrier with an IC50 value of 0.6 nM in hPBMCs. LRRK2-IN-3 can be used to study Parkinson's disease.
T63824	LRRK2-IN-2
	LRRK2-IN-2 is a selective, potent, and orally active LRRK2 inhibitor (IC50: 0.6 nM) that crosses the blood-brain barrier. LRRK2-IN-2 can be used to study Parkinson's disease.
T63621	LRRK2-IN-4
	LRRK2-IN-4 is a potent, selective, orally active, leucine-rich repeat kinase 2 (LRRK2) inhibitor that crosses the blood-brain barrier with an IC50 value of 2.6 nM. LRRK2-IN-3 has shown investigational potential in Parkin...
T62871	LRRK2-IN-6
	LRRK2-IN-6 (compound 22) is an orally active, selective leucine-rich repeat protein kinase 2 gene (LRRK2) inhibitor with blood-brain barrier permeability that inhibits GS LRRK2 (IC50: 4.6 μM) and WT LRRK2 (IC50: 49 μM). ...
T63057	LRRK2-IN-5
	LRRK2-IN-5 (compound 25) is an oral active, blood-brain barrier penetrating, selective leucine-rich repeat protein kinase 2 (LRRK2) inhibitor, which is effective for GS LRRK2 (IC50: 1.2 μM) and WT LRRK2 (IC50:16 μM) had ...
T79746	LRRK2-IN-10		LRRK2
	LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for...		LRRK2
T73176	LRRK2-IN-7
	LRRK2-IN-7 is a potent LRRK2 kinase inhibitor that demonstrates high selectivity and central nervous system (CNS) penetration, possessing an IC50 value of 0.9 nM. It exhibits more than 1000-fold selectivity against a bro...
T72421	LRRK2/NUAK1/TYK2-IN-1
	LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
T7155	JH-II-127		LRRK2
	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),		LRRK2
T1770	GNE-9605		LRRK2
	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).		LRRK2
T7729	PF-06454589		LRRK2
	PF-06454589 is a potent inhibitor of LRRK2.		LRRK2
T2022	CZC-54252	CZC54252,CZC 54252	LRRK2
	CZC-54252 is a potent inhibitor of LRRK2.		LRRK2
T5139	CZC-25146 hydrochloride		LRRK2
	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.		LRRK2
T39202	CZC-54252 hydrochloride		LRRK2
	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human...		LRRK2
T3053	CZC-25146	CHEMBL2397014	LRRK2
	CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.		LRRK2
T16115	MLi-2		LRRK2
	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce...		LRRK2
T2050	PF-06447475		LRRK2
	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.		LRRK2
T39972	EB-42486		LRRK2
	EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.		LRRK2