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CZC-54252

CZC-54252 is a potent inhibitor of LRRK2.

Catalog No. T2022Cas No. 1191911-27-9

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Purity:99.39%

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COA HNMR HPLC

CZC-54252

Catalog No. T2022Cas No. 1191911-27-9

CZC-54252 is a potent inhibitor of LRRK2.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$228	In Stock
50 mg	$346	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Product Introduction

Bioactivity

Description	CZC-54252 is a potent inhibitor of LRRK2.
Targets&IC50	LRRK2 (wild-type):1.28 nM (IC50), LRRK2 (G2019S):1.85 nM (IC50)
Alias	CZC54252, CZC 54252

Chemical Properties

Molecular Weight	504.99
Formula	C₂₂H₂₅ClN₆O₄S
Cas No.	1191911-27-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9802 mL	9.9012 mL	19.8024 mL	99.0119 mL
5 mM	0.3960 mL	1.9802 mL	3.9605 mL	19.8024 mL
10 mM	0.1980 mL	0.9901 mL	1.9802 mL	9.9012 mL
20 mM	0.0990 mL	0.4951 mL	0.9901 mL	4.9506 mL
50 mM	0.0396 mL	0.1980 mL	0.3960 mL	1.9802 mL
100 mM	0.0198 mL	0.0990 mL	0.1980 mL	0.9901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc