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JH-II-127

Catalog No. T7155 CAS 1700693-08-8

JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (<a href="/target/LRRK2" style="display: inline; color: #c13a36">LRRK2</a>). It inhibits WT <a href="/target/LRRK2" style="display: inline; color: #c13a36">LRRK2</a>, G2019S <a href="/target/LRRK2" style="display: inline; color: #c13a36">LRRK2</a> and A2016T <a href="/target/LRRK2" style="display: inline; color: #c13a36">LRRK2</a> (IC50s = 6.6, 2.2, and 47.7 nM, respectively),

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JH-II-127, CAS 1700693-08-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 87.00
5 mg	In stock	$ 134.00
10 mg	In stock	$ 205.00
25 mg	In stock	$ 369.00
50 mg	In stock	$ 633.00
100 mg	In stock	$ 1,066.00
1 mL * 10 mM (in DMSO)	In stock	$ 143.00

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Purity: 98%

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Description	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),
Targets&IC50	WT LRRK2:6.6 nM , G2019S LRRK2:2.2 nM , A2016T LRRK2:47.7 nM
In vivo	JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro.?It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

Molecular Weight	416.87
Formula	C19H21ClN6O3
CAS No.	1700693-08-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL (71.97 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor[J]. ACS Medicinal Chemistry Letters, 2015, 6(5):584-589.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parkinson's Disease Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Kinase Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Autophagy Compound Library Bioactive Compounds Library Max

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Related compounds with same targets

PF-06454589 JH-II-127 URMC-099 BIX 02565 CZC-25146 hydrochloride EB-42486 CZC-54252 hydrochloride CZC-25146

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Keywords

JH-II-127 1700693-08-8 Autophagy LRRK2 HEK293 JHII127 3T3 cells Inhibitor LRRK2-G2019S Ser935 Leucine-rich repeat kinase 2 parkinson’s disease inhibit JH II 127 LRRK2-A2016T inhibitor

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