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Search Results for " k12 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T39752	CDK12-IN-2	CDK12 inhibitor 2,CDK12-IN-2	CDK
	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CD...		CDK
T2079	GSK126	GSK2816126A,EZH2 inhibitor	Histone Methyltransferase
	GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).		Histone Methyltransferase
T63727	CRK12-IN-2		Parasite
	CRK12-IN-2 is a potent inhibitor of CRK12.CRK12-IN-2 inhibits the parasite, with EC50 values of 3.2 and 0.08 nM for Trypanosoma congolense and Trypanosoma vivax, respectively.CRK12-IN-2 can be used for the prevention and...		Parasite
T63059	CRK12-IN-1		Antibiotic
	CRK12-IN-1 is a potent CRK12 inhibitor.CRK12-IN-1 has insecticidal activity, with inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectivel...		Antibiotic
T2701	GSK1292263		GPR
	GSK1292263 is a GPR119 agonist and has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.		GPR
T24105	GSK121	GSK-121,GSK 121	PAD
	GSK121 is an inhibitor of selective PAD4.		PAD
T41085	UK122	UK122
	UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA),...
T40289	CDK12-IN-6	CDK12-IN-6
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not e...
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]...
T36095	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) can be used in related research in the field of life sciences, and its product number is T36095.
T14990	CDK12-IN-3		CDK
	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).		CDK
T40288	CDK12-IN-4	CDK12-IN-4
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or C...
T32001	GSK124576A	GSK-124576A,GSK 124576A
	GSK124576A is a bioactive chemical.
T14915	CDK12-IN-E9		CDK
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).		CDK
T64284	PROTAC CDK12/13 Degrader-1
	PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
T40290	CDK12-IN-5	CDK12-IN-5
	CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50...
T64172	MraY-IN-1
	MraY-IN-1 (compound 12a) is a potent inhibitor (IC50: 140 μM) of the bacterial translocase MraY. MraY-IN-1 has antibacterial activity against Escherichia coli K12 (MIC50: 7 μg/ml), Bacillus subtilis W23 (MIC50: 12 μg/ml)...
T78654	MraY-IN-3 hydrochloride
	MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM. This compound demonstrates antimicrobial activity, with MIC50 values of 7 µg/mL against Escherichia coli K12, 12 µg/mL for Bacillus su...
T64160	MraY-IN-3
	MraY-IN-3 (12a) is a potent inhibitor of the bacterial translocase MraY (IC50: 140 μM). 46 μg/ml).

Compounds

CDK12-IN-2

T39752

Synonym: CDK12 inhibitor 2,CDK12-IN-2

Target: CDK

GSK126

T2079

Synonym: GSK2816126A,EZH2 inhibitor

Target: Histone Methyltransferase

Synonym: GSK-121,GSK 121

Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

T36095

Synonym: Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Synonym: GSK-124576A,GSK 124576A

PROTAC CDK12/13 Degrader-1

MraY-IN-3 hydrochloride

Cat No.	Product Name	Synonyms	Targets
T13750	L-Fucitol	1-Deoxy-D-galactitol	Others
	L-Fucitol (1-Deoxy-D-galactitol) is a galactitol analogue isolated from Myristica fragrans (Nutmeg), inhibits galactitol-positive strains of Escherichia coli K12.		Others

Natural Products

L-Fucitol

T13750

Synonym: 1-Deoxy-D-galactitol

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02045	SECTM1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern a...
TMPK-00940	C-MPL Protein, Mouse, Recombinant (aa 26-482, His)	Mouse	HEK293 Cells
	C-MPL Protein, Mouse, Recombinant (aa 26-482, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 52.3 kDa and the accession number is Q08351-1.
TMPK-00877	C-MPL Protein, Human, Recombinant (aa 26-491, His)	Human	HEK293 Cells
	C-MPL Protein, Human, Recombinant (aa 26-491, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.6 kDa and the accession number is P40238-1.
TMPK-00494	C-MPL Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	C-MPL Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.48 kDa and the accession number is A0A2K5UGC7.
TMPK-00596	SECTM1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	SECTM1 is a T/NK cell "co-stimulatory" molecule that is expressed in the peripheral blood by neutrophils and monocytes.Human monocytic cells also displayed a pronounced negative regulation of SECTM1 mRNA expression by LP...
TMPJ-00039	FGF-2 Protein, Human, Recombinant (K128N)	Human	E. coli
	FGF-2 Protein, Human, Recombinant (K128N) is expressed in E. coli expression system. The predicted molecular weight is 17 KDa and the accession number is P09038-2.
TMPH-01806	OBP2A Protein, Human, Recombinant (C114S & K127N, His & SUMO)	Human	E. coli
	Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids. OBP2A Protein, Human, Recombinant (C114S & K127N, His & SUMO) is expressed in E. coli express...
TMPY-04430	P38 gamma/MAPK12 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
TMPY-04429	P38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
TMPY-04591	Influenza A H5N8 (A/duck/Jiangsu/k1203/2010) Hemagglutinin/HA1 Protein (His)	H5N8	HEK293 Cells
	Influenza A H5N8 (A/duck/Jiangsu/k1203/2010) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.7 kDa and the accession number is M9NJD2.
TMPH-03069	CSL3 Protein, Oncorhynchus keta, Recombinant (His)	Oncorhynchus keta	E. coli
	L-rhamnose binding lectin. Has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes and sheep erythrocytes. Hemagglutinating activity is i...